Linked Life Data

12225704

Source:http://linkedlifedata.com/resource/pubmed/id/12225704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-9-12
pubmed:abstractText
Lithium augmentation is a well established strategy for treatment-resistant depression. The exact mode of its action is unknown, but an enhancement of serotonergic transmission is hypothesized. The authors investigated changes in the hypothalamic-pituitary-adrenocortical (HPA) system during lithium augmentation and their correlation to clinical response by means of the combined dexamethasone/CRH test (DEX/CRH test). Thirty patients with unipolar major depressive episodes (DSM IV) who had not responded to an adequate trial with an antidepressant were assessed on the day before lithium augmentation (baseline) with the DEX/CRH test (pretreatment with 1.5 mg dexamethasone p.o. at 11 P.M. and CRH stimulation at 3 P.M. on the next day). Twenty-four patients were re-assessed after response was determined or, in cases of non-response, four weeks after initiation of lithium augmentation. Response to lithium augmentation was measured by weekly ratings on the Hamilton Depression Rating Scale (HDRS 17-item version). Response was defined as a DeltaHDRS of > or =50% and an endpoint score of < 10. Patients had a significantly higher ACTH and cortisol response to CRH stimulation during lithium augmentation compared with the values at baseline. There was no difference in ACTH and cortisol reaction between responders and non-responders to lithium augmentation. This increase is in contrast to the known normalization of HPA-axis overdrive after treatment with a tricyclic antidepressant like amitriptyline. Because the effect was independent of response status we suggest that this increase reflects an effect of lithium that is independent from the psychopathological state or its change. This effect might be explained by the serotonergic effects of lithium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
470-8
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed-meshheading:12225704-Adolescent, pubmed-meshheading:12225704-Adrenocorticotropic Hormone, pubmed-meshheading:12225704-Adult, pubmed-meshheading:12225704-Aged, pubmed-meshheading:12225704-Corticotropin-Releasing Hormone, pubmed-meshheading:12225704-Depressive Disorder, pubmed-meshheading:12225704-Dexamethasone, pubmed-meshheading:12225704-Drug Therapy, Combination, pubmed-meshheading:12225704-Female, pubmed-meshheading:12225704-Glucocorticoids, pubmed-meshheading:12225704-Humans, pubmed-meshheading:12225704-Hydrocortisone, pubmed-meshheading:12225704-Hypothalamo-Hypophyseal System, pubmed-meshheading:12225704-Lithium, pubmed-meshheading:12225704-Male, pubmed-meshheading:12225704-Matched-Pair Analysis, pubmed-meshheading:12225704-Middle Aged, pubmed-meshheading:12225704-Statistics, Nonparametric, pubmed-meshheading:12225704-Treatment Outcome
pubmed:year
2002
pubmed:articleTitle
Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression.
pubmed:affiliation
Department of Psychiatry, Technische Universität Dresden, Dresden, Germany. bschor@mailbox.tu-dresden.de
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't