rdf:type |
|
lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0015127,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021853,
umls-concept:C0040711,
umls-concept:C0076836,
umls-concept:C0162610,
umls-concept:C0333641,
umls-concept:C1199517,
umls-concept:C1314792,
umls-concept:C1419603,
umls-concept:C1848980
|
pubmed:issue |
17
|
pubmed:dateCreated |
2002-9-12
|
pubmed:abstractText |
TOR is a phosphatidylinositol kinase (PIK)-related kinase that controls cell growth and proliferation in response to nutritional cues. We describe a C. elegans TOR homolog (CeTOR) and phenotypes associated with CeTOR deficiency. These phenotypes are compared with the response to starvation and the inactivation of a variety of putative TOR targets.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0960-9822
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1448-61
|
pubmed:dateRevised |
2010-3-23
|
pubmed:meshHeading |
pubmed-meshheading:12225660-Adaptation, Physiological,
pubmed-meshheading:12225660-Alleles,
pubmed-meshheading:12225660-Animals,
pubmed-meshheading:12225660-Atrophy,
pubmed-meshheading:12225660-Caenorhabditis elegans,
pubmed-meshheading:12225660-Caenorhabditis elegans Proteins,
pubmed-meshheading:12225660-Eukaryotic Initiation Factor-2,
pubmed-meshheading:12225660-Eukaryotic Initiation Factor-4G,
pubmed-meshheading:12225660-Gene Expression Regulation, Developmental,
pubmed-meshheading:12225660-Gene Targeting,
pubmed-meshheading:12225660-Genes, Lethal,
pubmed-meshheading:12225660-Genetic Complementation Test,
pubmed-meshheading:12225660-Intestines,
pubmed-meshheading:12225660-Larva,
pubmed-meshheading:12225660-Phenotype,
pubmed-meshheading:12225660-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:12225660-Protein Biosynthesis,
pubmed-meshheading:12225660-RNA, Messenger,
pubmed-meshheading:12225660-RNA Interference,
pubmed-meshheading:12225660-Ribosomal Protein S6 Kinases, 70-kDa,
pubmed-meshheading:12225660-Sequence Homology, Amino Acid,
pubmed-meshheading:12225660-Sirolimus,
pubmed-meshheading:12225660-Species Specificity,
pubmed-meshheading:12225660-Starvation
|
pubmed:year |
2002
|
pubmed:articleTitle |
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation.
|
pubmed:affiliation |
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|