Source:http://linkedlifedata.com/resource/pubmed/id/12224054
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0007452,
umls-concept:C0010453,
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umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1383501,
umls-concept:C1698986,
umls-concept:C1880497,
umls-concept:C1963578,
umls-concept:C1996904
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| pubmed:issue |
7
|
| pubmed:dateCreated |
2002-9-11
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| pubmed:abstractText |
This study was made to explain the mechanisms for the effects of exposure to a time varying 1.51 T magnetic field on the intracellular Ca(2+) signaling pathway. The exposure inhibited an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in bovine chromaffin cells induced by addition of bradykinin (BK) to a Ca(2+) free medium. The exposure did not change BK induced production of inositol 1,4,5-trisphosphate (IP(3)). [Ca(2+)](i) was markedly increased in IP(3) loaded cells, and this increase was inhibited by the magnetic field exposure. A similar increase in [Ca(2+)](i) by other drugs, which stimulated Ca(2+) release from intracellular Ca(2+) stores, was again inhibited by the same exposure. However, transmembrane Ca(2+) fluxes caused in the presence of thapsigargin were not inhibited by the magnetic field exposure in a Ca(2+) containing medium. Inhibition of the BK induced increase in [Ca(2+)](i) by the exposure for 30 min was mostly recovered 1 h after exposure ended. Our results reveal that the magnetic field exposure inhibits Ca(2+) release from intracellular Ca(2+) stores, but that BK bindings to BK receptors of the cell membrane and intracellular inositol IP(3) production are not influenced.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0197-8462
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| pubmed:author |
pubmed-author:AzumaMamiM,
pubmed-author:HosokawaKeikoK,
pubmed-author:HouchiHitoshiH,
pubmed-author:IkeharaToshitakaT,
pubmed-author:KashimotoHidekiH,
pubmed-author:KinouchiYohsukeY,
pubmed-author:KitamuraMitsuoM,
pubmed-author:MinakuchiKazuoK,
pubmed-author:MiyamotoHiroshiH,
pubmed-author:ParkKi HoKH,
pubmed-author:YamaguchiHisaoH,
pubmed-author:YoshizakiKazuoK
|
| pubmed:copyrightInfo |
Copyright 2002 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:volume |
23
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
505-15
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12224054-Adrenal Glands,
pubmed-meshheading:12224054-Animals,
pubmed-meshheading:12224054-Biological Transport,
pubmed-meshheading:12224054-Bradykinin,
pubmed-meshheading:12224054-Calcium,
pubmed-meshheading:12224054-Cattle,
pubmed-meshheading:12224054-Cells,
pubmed-meshheading:12224054-Chromaffin Cells,
pubmed-meshheading:12224054-Electromagnetic Fields,
pubmed-meshheading:12224054-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:12224054-Signal Transduction,
pubmed-meshheading:12224054-Time Factors
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| pubmed:year |
2002
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| pubmed:articleTitle |
Effects of a time varying strong magnetic field on release of cytosolic free Ca2+ from intracellular stores in cultured bovine adrenal chromaffin cells.
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| pubmed:affiliation |
Department of Physiology, School of Medicine, The University of Tokushima, Kuramoto-cho, Tokushima 770-8503, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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