Source:http://linkedlifedata.com/resource/pubmed/id/12221641
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2002-9-10
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pubmed:abstractText |
Helper-dependent, or gutted, adenoviruses (Ad) lack viral coding sequences, resulting in reduced immunotoxicity compared with conventional Ad vectors. Gutted Ad growth requires a conventional Ad to supply replication and packaging functions in trans. Methods that allow high-titer growth of gutted vectors while reducing helper contamination, and which use safer helper viruses, will facilitate the use of gutted Ad vectors in vivo.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1099-498X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2002 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
480-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12221641-Adenoviridae,
pubmed-meshheading:12221641-Adenovirus Early Proteins,
pubmed-meshheading:12221641-Genetic Vectors,
pubmed-meshheading:12221641-Helper Viruses,
pubmed-meshheading:12221641-Humans,
pubmed-meshheading:12221641-Integrases,
pubmed-meshheading:12221641-Viral Proteins
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pubmed:articleTitle |
Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses.
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pubmed:affiliation |
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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