|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2002-9-10
|
|
pubmed:abstractText |
Adriamycin (ADR) is an anticancer drug known to cause severe cardiac toxicity by generating free radicals. We investigated the role of a redox-regulating molecule, thioredoxin-1 (TRX1), in ADR-induced cardiotoxicity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
10
|
|
pubmed:volume |
106
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1403-9
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12221060-Animals,
pubmed-meshheading:12221060-Animals, Newborn,
pubmed-meshheading:12221060-Antineoplastic Agents,
pubmed-meshheading:12221060-Cardiomyopathies,
pubmed-meshheading:12221060-Cardiotonic Agents,
pubmed-meshheading:12221060-Cells, Cultured,
pubmed-meshheading:12221060-Doxorubicin,
pubmed-meshheading:12221060-Hydroxyl Radical,
pubmed-meshheading:12221060-Membrane Proteins,
pubmed-meshheading:12221060-Mice,
pubmed-meshheading:12221060-Mice, Transgenic,
pubmed-meshheading:12221060-Myocardium,
pubmed-meshheading:12221060-Oxidation-Reduction,
pubmed-meshheading:12221060-Oxidative Stress,
pubmed-meshheading:12221060-Proteins,
pubmed-meshheading:12221060-Rats,
pubmed-meshheading:12221060-Rats, Inbred Lew,
pubmed-meshheading:12221060-Reactive Oxygen Species,
pubmed-meshheading:12221060-Survival Analysis,
pubmed-meshheading:12221060-Thioredoxins,
pubmed-meshheading:12221060-Up-Regulation
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity.
|
|
pubmed:affiliation |
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
