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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2002-9-10
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pubmed:abstractText |
Lipid lowering may reduce acute coronary events in patients in part by reducing vascular inflammation. Oxidative stress induces endothelial cell (EC) expression of vascular cell adhesion molecule 1 (VCAM-1) and monocyte chemoattractant protein 1 (MCP-1) and reduces levels of atheroprotective NO, leading to monocyte recruitment and macrophage accumulation. This study tested the hypothesis that lipid lowering decreases oxidative stress and improves EC functions related to inflammatory cell accumulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein B-100,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1390-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12221058-Animals,
pubmed-meshheading:12221058-Aorta,
pubmed-meshheading:12221058-Apolipoprotein B-100,
pubmed-meshheading:12221058-Apolipoproteins B,
pubmed-meshheading:12221058-Arteriosclerosis,
pubmed-meshheading:12221058-Autoantibodies,
pubmed-meshheading:12221058-Chemokine CCL2,
pubmed-meshheading:12221058-Culture Techniques,
pubmed-meshheading:12221058-Diet, Atherogenic,
pubmed-meshheading:12221058-Endothelium, Vascular,
pubmed-meshheading:12221058-Hypercholesterolemia,
pubmed-meshheading:12221058-Lipids,
pubmed-meshheading:12221058-Lipoproteins, LDL,
pubmed-meshheading:12221058-Male,
pubmed-meshheading:12221058-Nitric Oxide Synthase,
pubmed-meshheading:12221058-Nitric Oxide Synthase Type III,
pubmed-meshheading:12221058-Oxidative Stress,
pubmed-meshheading:12221058-Rabbits,
pubmed-meshheading:12221058-Reactive Oxygen Species,
pubmed-meshheading:12221058-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2002
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pubmed:articleTitle |
Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma.
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pubmed:affiliation |
Leducq Center for Cardiovascular Research, Department of Medicine, University of California, San Diego, La Jolla, Calif, USA. maikawa@rics.bwh.harvard.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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