Linked Life Data

12220632

Source:http://linkedlifedata.com/resource/pubmed/id/12220632

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2002-9-10
pubmed:abstractText
Membrane type-1 matrix metalloproteinase (MT1-MMP), a key enzyme in cell locomotion, is known to be primarily recruited to the leading edge of migrating cells. This raises a possibility that the C-terminal cytoplasmic tail of MT1-MMP interacts with intracellular regulatory proteins, which modulate translocations of the protease across the cell. Here, we demonstrated that MT1-MMP via its cytoplasmic tail directly associates with a chaperone-like compartment-specific regulator gC1qR. Although a direct functional link between these two proteins remains uncertain, our observations suggest that the transient associations of gC1qR with the cytoplasmic tail of MT1-MMP are likely to be involved in the mechanisms regulating presentation of the protease at the tumor cell surface.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
527
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12220632-Amino Acid Sequence, pubmed-meshheading:12220632-Antigens, CD44, pubmed-meshheading:12220632-Binding Sites, pubmed-meshheading:12220632-Breast Neoplasms, pubmed-meshheading:12220632-Carrier Proteins, pubmed-meshheading:12220632-Cell Compartmentation, pubmed-meshheading:12220632-Cytoplasm, pubmed-meshheading:12220632-Humans, pubmed-meshheading:12220632-Matrix Metalloproteinases, Membrane-Associated, pubmed-meshheading:12220632-Membrane Glycoproteins, pubmed-meshheading:12220632-Metalloendopeptidases, pubmed-meshheading:12220632-Mitochondrial Proteins, pubmed-meshheading:12220632-Molecular Sequence Data, pubmed-meshheading:12220632-Peptide Fragments, pubmed-meshheading:12220632-Precipitin Tests, pubmed-meshheading:12220632-Receptors, Complement, pubmed-meshheading:12220632-Tumor Cells, Cultured
pubmed:year
2002
pubmed:articleTitle
The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein.
pubmed:affiliation
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't