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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4-5
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pubmed:dateCreated |
2002-9-10
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pubmed:abstractText |
Fas antigen (Fas) is a cell surface receptor molecule introducing apoptosis-inducing signals into Fas-bearing cells by stimulation with Fas ligand or agonistic anti-Fas monoclonal antibodies. Fas system has been implicated in the regulation of homeostasis of peripheral T and B lymphocytes including elimination of autoreactive cells, and in the exclusion of tumor and virus-infected cells. Fas system, however, also plays a role in the mechanisms responsible for tissue disruption in tissue-specific autoimmune disease and fulminant hepatitis. In this review, I describe how we prepared the original anti-human Fas monoclonal antibody with associated cell-killing activity, and I propose here a strategy of therapeutic use of a novel anti-Fas monoclonal antibody for autoimmune and other diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1359-6101
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
393-402
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12220552-Animals,
pubmed-meshheading:12220552-Antibodies, Monoclonal,
pubmed-meshheading:12220552-Antigens, CD95,
pubmed-meshheading:12220552-Apoptosis,
pubmed-meshheading:12220552-Autoimmune Diseases,
pubmed-meshheading:12220552-Cricetinae,
pubmed-meshheading:12220552-Cross Reactions,
pubmed-meshheading:12220552-Disease Models, Animal,
pubmed-meshheading:12220552-Fas Ligand Protein,
pubmed-meshheading:12220552-Forecasting,
pubmed-meshheading:12220552-Hepatitis,
pubmed-meshheading:12220552-Humans,
pubmed-meshheading:12220552-Immunologic Surveillance,
pubmed-meshheading:12220552-Lymphoproliferative Disorders,
pubmed-meshheading:12220552-Membrane Glycoproteins,
pubmed-meshheading:12220552-Mice,
pubmed-meshheading:12220552-Mice, Inbred MRL lpr,
pubmed-meshheading:12220552-Mice, Inbred Strains,
pubmed-meshheading:12220552-Organ Specificity,
pubmed-meshheading:12220552-Species Specificity,
pubmed-meshheading:12220552-T-Lymphocyte Subsets
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pubmed:articleTitle |
Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody.
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pubmed:affiliation |
Graduate School of Biostudies and Institute for Virus Research, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. syonehar@virus.kyoto-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't
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