| pubmed-article:12219089 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:12219089 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12219089 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12219089 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:12219089 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:12219089 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12219089 | pubmed:dateCreated | 2002-9-30 | lld:pubmed |
| pubmed-article:12219089 | pubmed:abstractText | Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light. Bright light induces apoptosis that is independent of transducin and accompanied by induction of the transcription factor AP-1. By contrast, low light induces an apoptotic pathway that requires transducin. We also provide evidence that additional genetic factors regulate sensitivity to light-induced damage. Our use of defined mouse mutants resolves some of the complexity underlying the mechanisms that regulate susceptibility to retinal degeneration. | lld:pubmed |
| pubmed-article:12219089 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12219089 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12219089 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12219089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12219089 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12219089 | pubmed:issn | 1061-4036 | lld:pubmed |
| pubmed-article:12219089 | pubmed:author | pubmed-author:SimonMelvin... | lld:pubmed |
| pubmed-article:12219089 | pubmed:author | pubmed-author:WenzelAndreas... | lld:pubmed |
| pubmed-article:12219089 | pubmed:author | pubmed-author:GrimmChristia... | lld:pubmed |
| pubmed-article:12219089 | pubmed:author | pubmed-author:TaylorAllenA | lld:pubmed |
| pubmed-article:12219089 | pubmed:author | pubmed-author:ReméCharlotte... | lld:pubmed |
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| pubmed-article:12219089 | pubmed:author | pubmed-author:HaoWenshanW | lld:pubmed |
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| pubmed-article:12219089 | pubmed:author | pubmed-author:ChenChing-Kan... | lld:pubmed |
| pubmed-article:12219089 | pubmed:author | pubmed-author:BrillElliottE | lld:pubmed |
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| pubmed-article:12219089 | pubmed:author | pubmed-author:LemJanisJ | lld:pubmed |
| pubmed-article:12219089 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12219089 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:12219089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12219089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12219089 | pubmed:pagination | 254-60 | lld:pubmed |
| pubmed-article:12219089 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12219089 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12219089 | pubmed:articleTitle | Evidence for two apoptotic pathways in light-induced retinal degeneration. | lld:pubmed |
| pubmed-article:12219089 | pubmed:affiliation | Division of Biology, California Institute of Technology, Pasadena, California 91125, USA. | lld:pubmed |
| pubmed-article:12219089 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12219089 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12219089 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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