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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-9-30
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pubmed:abstractText |
Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light. Bright light induces apoptosis that is independent of transducin and accompanied by induction of the transcription factor AP-1. By contrast, low light induces an apoptotic pathway that requires transducin. We also provide evidence that additional genetic factors regulate sensitivity to light-induced damage. Our use of defined mouse mutants resolves some of the complexity underlying the mechanisms that regulate susceptibility to retinal degeneration.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arrestin,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/G-Protein-Coupled Receptor Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Grk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rhodopsin,
http://linkedlifedata.com/resource/pubmed/chemical/Rpe65 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Transducin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:BrillElliottE,
pubmed-author:ChenChing-KangCK,
pubmed-author:Eversole-CirePamelaP,
pubmed-author:GrimmChristianC,
pubmed-author:HaoWenshanW,
pubmed-author:KleynerYelenaY,
pubmed-author:KrasnoperovaNataliia VNV,
pubmed-author:LemJanisJ,
pubmed-author:ObinMartin SMS,
pubmed-author:ReméCharlotte ECE,
pubmed-author:SimonMelvin IMI,
pubmed-author:TaylorAllenA,
pubmed-author:WenzelAndreasA
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
254-60
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12219089-Animals,
pubmed-meshheading:12219089-Apoptosis,
pubmed-meshheading:12219089-Arrestin,
pubmed-meshheading:12219089-Carrier Proteins,
pubmed-meshheading:12219089-Dexamethasone,
pubmed-meshheading:12219089-Eye Proteins,
pubmed-meshheading:12219089-G-Protein-Coupled Receptor Kinase 1,
pubmed-meshheading:12219089-Light,
pubmed-meshheading:12219089-Mice,
pubmed-meshheading:12219089-Mice, Inbred BALB C,
pubmed-meshheading:12219089-Mice, Inbred C57BL,
pubmed-meshheading:12219089-Mutation,
pubmed-meshheading:12219089-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:12219089-Protein Kinases,
pubmed-meshheading:12219089-Proteins,
pubmed-meshheading:12219089-Retina,
pubmed-meshheading:12219089-Rhodopsin,
pubmed-meshheading:12219089-Signal Transduction,
pubmed-meshheading:12219089-Transcription Factor AP-1,
pubmed-meshheading:12219089-Transducin
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pubmed:year |
2002
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pubmed:articleTitle |
Evidence for two apoptotic pathways in light-induced retinal degeneration.
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pubmed:affiliation |
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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