rdf:type |
|
lifeskim:mentions |
umls-concept:C0014597,
umls-concept:C0021853,
umls-concept:C0040648,
umls-concept:C0060001,
umls-concept:C0085295,
umls-concept:C0086418,
umls-concept:C0086860,
umls-concept:C0108685,
umls-concept:C1515877,
umls-concept:C1704829,
umls-concept:C1879547
|
pubmed:issue |
2
|
pubmed:dateCreated |
2002-9-9
|
pubmed:abstractText |
Interleukin (IL)-6 is produced by enterocytes in response to sepsis and after treatment with IL-1beta. The IL-6 promoter contains binding sites for multiple transcription factors, including nuclear factor-kappaB and C/EBP. The anti-inflammatory cytokine IL-10 downregulates nuclear factor-kappaB activity, but its effects on C/EBP activation and IL-6 production in the enterocyte are not known.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0039-6060
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
132
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
226-31
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:12219016-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:12219016-Caco-2 Cells,
pubmed-meshheading:12219016-Enterocytes,
pubmed-meshheading:12219016-Gene Expression Regulation,
pubmed-meshheading:12219016-Humans,
pubmed-meshheading:12219016-Interleukin-1,
pubmed-meshheading:12219016-Interleukin-10,
pubmed-meshheading:12219016-Interleukin-4,
pubmed-meshheading:12219016-Interleukin-6,
pubmed-meshheading:12219016-Intestinal Mucosa,
pubmed-meshheading:12219016-Promoter Regions, Genetic,
pubmed-meshheading:12219016-Transcriptional Activation
|
pubmed:year |
2002
|
pubmed:articleTitle |
Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells.
|
pubmed:affiliation |
Department of Surgery, University of Cincinnati, Ohio, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|