Source:http://linkedlifedata.com/resource/pubmed/id/12218659
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2002-9-9
|
| pubmed:abstractText |
Tissue inhibitor of metalloproteinases 1 (TIMP-1) inhibits several proteinases including a disintegrin and metalloproteinase 10 (ADAM10), a major alpha-secretase that cleaves the beta-amyloid precursor protein within its amyloidogenic Abeta domain. The gene encoding TIMP-1 (TIMP 1) maps to the short arm of the X chromosome, in a region previously suggested as conferring genetic susceptibility for Alzheimer's disease (AD). To determine whether genetic variability of TIMP 1 contributes to the pathogenesis of AD, we analysed one single nucleotide polymorphism within TIMP 1 and one single nucleotide polymorphism in the 5'-untranslated region of TIMP 1 in patients with AD and control subjects from two independent and ethnically different populations. We did not observe any association between TIMP 1 genotypes and the diagnosis of AD in men or women. We also measured TIMP-1 protein levels in the cerebrospinal fluid of patients with AD, healthy control subjects, and patients with other neurological disorders. TIMP-1 levels were similar in all groups. In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0955-8829
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| pubmed:author |
pubmed-author:BieberClaudiaC,
pubmed-author:BosshardtSimoneS,
pubmed-author:DegondaNadiaN,
pubmed-author:GrimaldiLuigi M ELM,
pubmed-author:HegiThomasT,
pubmed-author:HenkeKatharinaK,
pubmed-author:HockChristophC,
pubmed-author:JungHans HHH,
pubmed-author:KapakiElisabethE,
pubmed-author:LemkeUlrikeU,
pubmed-author:MaddalenaAlessiaA,
pubmed-author:NitschRoger MRM,
pubmed-author:PapassotiropoulosAndreasA,
pubmed-author:ParaskevasGeorge PGP,
pubmed-author:PaschThomasT,
pubmed-author:SalaniGiulianaG,
pubmed-author:StrefferJohannes RJR,
pubmed-author:UmbrichtDanielD,
pubmed-author:WollmerM AxelMA,
pubmed-author:de QuervainDominiqueD
|
| pubmed:copyrightInfo |
Copyright 2002 Lippincott Williams & Wilkins
|
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
155-60
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:12218659-5' Untranslated Regions,
pubmed-meshheading:12218659-Alzheimer Disease,
pubmed-meshheading:12218659-Chromosome Mapping,
pubmed-meshheading:12218659-Chromosomes, Human, X,
pubmed-meshheading:12218659-DNA,
pubmed-meshheading:12218659-Female,
pubmed-meshheading:12218659-Gene Frequency,
pubmed-meshheading:12218659-Genetic Variation,
pubmed-meshheading:12218659-Humans,
pubmed-meshheading:12218659-Male,
pubmed-meshheading:12218659-Polymorphism, Genetic,
pubmed-meshheading:12218659-Polymorphism, Single Nucleotide,
pubmed-meshheading:12218659-Reference Values,
pubmed-meshheading:12218659-Tissue Inhibitor of Metalloproteinase-1
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease.
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| pubmed:affiliation |
Division of Psychiatry Research, University of Zurich, Switzerland. awollmer@bli.unizh.ch
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|