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rdf:type |
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lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0004561,
umls-concept:C0035647,
umls-concept:C0086418,
umls-concept:C0439098,
umls-concept:C0599894,
umls-concept:C1514562,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2754974
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pubmed:issue |
4
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pubmed:dateCreated |
2002-9-9
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pubmed:abstractText |
IgE mediates immediate-type hypersensitivity reactions responsible for various allergic symptoms. It is secreted by IgE-producing plasma cells, which differentiate from B cells expressing membrane-bound IgE (mIgE) on their surface. The epsilon-chain of human mIgE contains a membrane-anchoring peptide and an extra 52-amino-acid (a.a.)-long domain (referred to as C(epsilon)mX) between the membrane anchor and the CH4 domain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1018-2438
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-24
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12218370-Amino Acid Sequence,
pubmed-meshheading:12218370-Animals,
pubmed-meshheading:12218370-Antibodies, Monoclonal,
pubmed-meshheading:12218370-B-Lymphocytes,
pubmed-meshheading:12218370-Binding, Competitive,
pubmed-meshheading:12218370-CHO Cells,
pubmed-meshheading:12218370-Cell Line,
pubmed-meshheading:12218370-Complement Activation,
pubmed-meshheading:12218370-Cricetinae,
pubmed-meshheading:12218370-Drug Delivery Systems,
pubmed-meshheading:12218370-Epitope Mapping,
pubmed-meshheading:12218370-Hybridomas,
pubmed-meshheading:12218370-Hypersensitivity, Immediate,
pubmed-meshheading:12218370-Immunoblotting,
pubmed-meshheading:12218370-Immunoglobulin Fc Fragments,
pubmed-meshheading:12218370-Immunoglobulin epsilon-Chains,
pubmed-meshheading:12218370-Mass Spectrometry,
pubmed-meshheading:12218370-Membrane Proteins,
pubmed-meshheading:12218370-Mice,
pubmed-meshheading:12218370-Mice, Inbred BALB C,
pubmed-meshheading:12218370-Molecular Sequence Data,
pubmed-meshheading:12218370-Protein Structure, Tertiary,
pubmed-meshheading:12218370-Receptor Aggregation,
pubmed-meshheading:12218370-Recombinant Fusion Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Monoclonal antibodies against the C(epsilon)mX domain of human membrane-bound IgE and their potential use for targeting IgE-expressing B cells.
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pubmed:affiliation |
Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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