Linked Life Data

12218365

Source:http://linkedlifedata.com/resource/pubmed/id/12218365

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-9-9
pubmed:abstractText
Both latex-fruit syndrome and oral allergy syndrome concomitant with pollinosis (pollen-food allergy syndrome) are considered to be caused by cross-reactivity between sensitizers and symptom elicitors. The cross-reactive food allergens relevant to these syndromes are mostly sensitive to heat and digestive enzymes. Such a vulnerable antigen cannot sensitize people perorally but provokes allergic reactions in already sensitized patients based on its cross-reactivity to the corresponding sensitizer. These types of food allergens are often called incomplete food allergens or nonsensitizing elicitors. Their features contrast with those of complete food allergens that have the capacity for peroral sensitization as well as symptom elicitation. Although highly antigenic and cross-reactive, carbohydrate epitopes do not generally elicit allergic reactions and often disturb in vitro IgE tests. Recent research has revealed that some of the cross-reactive allergens responsible for the two syndromes are proteins related to the defense responses of higher plants. Plant defense-related proteins are relatively conserved in the course of evolution and can supply cross-reactive epitopes. It is important to note that various stresses can stimulate the expression of these proteins, which implies that allergens increase in plants under stressful conditions like severe growing situations and exposure to some kinds of chemicals. Because defense-related proteins usually provide a plant with resistance to stresses, varieties that are apt to intensively induce such proteins are agriculturally valuable. Less toxic substances that cause crops to express defensive proteins are being investigated as a new type of agrochemical. Moreover, some defense-related proteins are going to be constantly produced in genetically modified plants. Even though these proteins can be useful agriculturally, their allergenicity should be evaluated carefully.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1018-2438
pubmed:author
pubmed:copyrightInfo
Copyright 2002 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Allergies to cross-reactive plant proteins. Latex-fruit syndrome is comparable with pollen-food allergy syndrome.
pubmed:affiliation
Division of Medical Devices, National Institute of Health Sciences, Kamiyoga, Setagaya-Ku, Tokyo, Japan. yagami@nihs.go.jp
pubmed:publicationType
Journal Article, Comparative Study, Review