| pubmed-article:12218137 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C1261473 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C0684321 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12218137 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:12218137 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12218137 | pubmed:dateCreated | 2002-9-9 | lld:pubmed |
| pubmed-article:12218137 | pubmed:abstractText | Despite the accepted role for CD4+ T cells in immune control, little is known about the development of Ag-specific CD4+ T cell immunity upon primary infection. Here we use MHC class II tetramer technology to directly visualize the Ag-specific CD4+ T cell response upon infection of mice with Moloney murine sarcoma and leukemia virus complex (MoMSV). Significant numbers of Ag-specific CD4+ T cells are detected both in lymphoid organs and in retrovirus-induced lesions early during infection, and they express the 1B11-reactive activation-induced isoform of CD43 that was recently shown to define effector CD8+ T cell populations. Comparison of the kinetics of the MoMSV-specific CD4+ and CD8+ T cell responses reveals a pronounced shift toward CD8+ T cell immunity at the site of MoMSV infection during progression of the immune response. Consistent with an important early role of Ag-specific CD4+ T cell immunity during MoMSV infection, CD4+ T cells contribute to the generation of virus-specific CD8+ T cell immunity within the lymphoid organs and are required to promote an inflammatory environment within the virus-infected tissue. | lld:pubmed |
| pubmed-article:12218137 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12218137 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12218137 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12218137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12218137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12218137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12218137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12218137 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12218137 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12218137 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:SchumacherTon... | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:MeliefCorneli... | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:SchepersKoenK | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:OssendorpFerr... | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:Vyth-DreeseFl... | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:ToebesMireill... | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:SotthewesGitt... | lld:pubmed |
| pubmed-article:12218137 | pubmed:author | pubmed-author:DellemijnTree... | lld:pubmed |
| pubmed-article:12218137 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12218137 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12218137 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:12218137 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12218137 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12218137 | pubmed:pagination | 3191-9 | lld:pubmed |
| pubmed-article:12218137 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12218137 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12218137 | pubmed:articleTitle | Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas. | lld:pubmed |
| pubmed-article:12218137 | pubmed:affiliation | Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:12218137 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12218137 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12218137 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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