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rdf:type |
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lifeskim:mentions |
umls-concept:C0022702,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0443199,
umls-concept:C0684321,
umls-concept:C0871261,
umls-concept:C1261473,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
2002-9-9
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|
pubmed:abstractText |
Despite the accepted role for CD4+ T cells in immune control, little is known about the development of Ag-specific CD4+ T cell immunity upon primary infection. Here we use MHC class II tetramer technology to directly visualize the Ag-specific CD4+ T cell response upon infection of mice with Moloney murine sarcoma and leukemia virus complex (MoMSV). Significant numbers of Ag-specific CD4+ T cells are detected both in lymphoid organs and in retrovirus-induced lesions early during infection, and they express the 1B11-reactive activation-induced isoform of CD43 that was recently shown to define effector CD8+ T cell populations. Comparison of the kinetics of the MoMSV-specific CD4+ and CD8+ T cell responses reveals a pronounced shift toward CD8+ T cell immunity at the site of MoMSV infection during progression of the immune response. Consistent with an important early role of Ag-specific CD4+ T cell immunity during MoMSV infection, CD4+ T cells contribute to the generation of virus-specific CD8+ T cell immunity within the lymphoid organs and are required to promote an inflammatory environment within the virus-infected tissue.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3191-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12218137-Amino Acid Sequence,
pubmed-meshheading:12218137-Amino Acid Substitution,
pubmed-meshheading:12218137-Animals,
pubmed-meshheading:12218137-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12218137-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12218137-Epitopes, T-Lymphocyte,
pubmed-meshheading:12218137-Histocompatibility Antigens Class I,
pubmed-meshheading:12218137-Histocompatibility Antigens Class II,
pubmed-meshheading:12218137-Immunity, Cellular,
pubmed-meshheading:12218137-Immunophenotyping,
pubmed-meshheading:12218137-Kinetics,
pubmed-meshheading:12218137-Lymphocyte Activation,
pubmed-meshheading:12218137-Mice,
pubmed-meshheading:12218137-Mice, Inbred C57BL,
pubmed-meshheading:12218137-Molecular Sequence Data,
pubmed-meshheading:12218137-Moloney murine leukemia virus,
pubmed-meshheading:12218137-Moloney murine sarcoma virus,
pubmed-meshheading:12218137-Peptide Fragments,
pubmed-meshheading:12218137-Remission, Spontaneous,
pubmed-meshheading:12218137-Sarcoma, Experimental,
pubmed-meshheading:12218137-Tumor Virus Infections
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pubmed:year |
2002
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pubmed:articleTitle |
Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas.
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pubmed:affiliation |
Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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