| pubmed-article:12217876 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12217876 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12217876 | lifeskim:mentions | umls-concept:C0126037 | lld:lifeskim |
| pubmed-article:12217876 | lifeskim:mentions | umls-concept:C1413273 | lld:lifeskim |
| pubmed-article:12217876 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:12217876 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12217876 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12217876 | pubmed:dateCreated | 2002-9-9 | lld:pubmed |
| pubmed-article:12217876 | pubmed:abstractText | Kidney-specific cadherin (Ksp-cadherin) is a tissue-specific member of the cadherin family that is expressed exclusively in the kidney and developing genitourinary tract. Recent studies have shown that the proximal 250 bp of the Ksp-cadherin gene promoter are sufficient to direct tissue-specific gene expression in vivo and in vitro. The proximal 120 bp of the promoter are evolutionarily conserved between mouse and human and contain a DNase I hypersensitive site that is kidney cell specific. At position -55, the promoter contains a consensus recognition site for hepatocyte nuclear factor-1 (HNF-1). Mutations of the consensus HNF-1 site and downstream GC-boxes inhibit promoter activity in transfected cells. HNF-1alpha and HNF-1beta bind specifically to the -55 site, and both proteins transactivate the promoter directly. Expression of Ksp-cadherin is not altered in the kidneys of HNF-1alpha-deficient mice. However, expression of a gain-of-function HNF-1beta mutant stimulates Ksp-cadherin promoter activity in transfected cells, whereas expression of a dominant-negative mutant inhibits activity. These studies identify Ksp-cadherin as the first kidney-specific promoter that has been shown to be regulated by HNF-1beta. Mutations of HNF-1beta, as occur in humans with inherited renal cysts and diabetes, may cause dysregulated Ksp-cadherin promoter activity. | lld:pubmed |
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| pubmed-article:12217876 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12217876 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12217876 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12217876 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12217876 | pubmed:issn | 1931-857X | lld:pubmed |
| pubmed-article:12217876 | pubmed:author | pubmed-author:HiesbergerTho... | lld:pubmed |
| pubmed-article:12217876 | pubmed:author | pubmed-author:PontoglioMarc... | lld:pubmed |
| pubmed-article:12217876 | pubmed:author | pubmed-author:IgarashiPeter... | lld:pubmed |
| pubmed-article:12217876 | pubmed:author | pubmed-author:SinclairAngus... | lld:pubmed |
| pubmed-article:12217876 | pubmed:author | pubmed-author:YinBeiB | lld:pubmed |
| pubmed-article:12217876 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12217876 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:12217876 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12217876 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12217876 | pubmed:pagination | F839-51 | lld:pubmed |
| pubmed-article:12217876 | pubmed:dateRevised | 2011-4-28 | lld:pubmed |
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| pubmed-article:12217876 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12217876 | pubmed:articleTitle | Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1beta. | lld:pubmed |
| pubmed-article:12217876 | pubmed:affiliation | Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390, USA. | lld:pubmed |
| pubmed-article:12217876 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12217876 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12217876 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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