|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2002-9-9
|
|
pubmed:abstractText |
Orexin-A is an endogenous peptide with receptors present throughout the brain. Here, we examined the effect of post-training administration of orexin-A on retention in active and passive avoidance. Orexin-A administered by intracerebroventricular (i.c.v.) injection to CD-1 mice post-training improved retention in both T-maze footshock avoidance and one trial step-down passive avoidance. SAMP8 mice have age-related deficits in learning and memory, which correlate with an increase in brain levels of beta amyloid (Abeta) and an impaired response to memory-enhancing compounds. Orexin-A at 3nmol improved retention in young and old SAMP8 mice. These findings show that orexin-A can improve memory even with overproduction of Abeta.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0196-9781
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1683-8
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12217429-Amyloid beta-Peptides,
pubmed-meshheading:12217429-Animals,
pubmed-meshheading:12217429-Avoidance Learning,
pubmed-meshheading:12217429-Brain,
pubmed-meshheading:12217429-Carrier Proteins,
pubmed-meshheading:12217429-Dose-Response Relationship, Drug,
pubmed-meshheading:12217429-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12217429-Male,
pubmed-meshheading:12217429-Maze Learning,
pubmed-meshheading:12217429-Memory,
pubmed-meshheading:12217429-Mice,
pubmed-meshheading:12217429-Neuropeptides,
pubmed-meshheading:12217429-Time Factors
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Effects of orexin-A on memory processing.
|
|
pubmed:affiliation |
Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO 63106, USA.
|
|
pubmed:publicationType |
Journal Article
|
