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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2002-9-9
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pubmed:abstractText |
Some benzimidazolyl sulphones were synthesized and evaluated for their antiviral and antiproliferative properties. Compound 10 displayed significant and selective activity against human cytomegalovirus (CMV), compound 14 showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives. Some structure-activity relationships are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2707-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12217359-Animals,
pubmed-meshheading:12217359-Antineoplastic Agents,
pubmed-meshheading:12217359-Antiviral Agents,
pubmed-meshheading:12217359-Benzimidazoles,
pubmed-meshheading:12217359-Cytomegalovirus,
pubmed-meshheading:12217359-Drug Screening Assays, Antitumor,
pubmed-meshheading:12217359-Herpesvirus 3, Human,
pubmed-meshheading:12217359-Humans,
pubmed-meshheading:12217359-Mice,
pubmed-meshheading:12217359-Structure-Activity Relationship,
pubmed-meshheading:12217359-T-Lymphocytes,
pubmed-meshheading:12217359-Tumor Cells, Cultured,
pubmed-meshheading:12217359-Viral Plaque Assay
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pubmed:year |
2002
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pubmed:articleTitle |
Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
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pubmed:affiliation |
Department of Pharmaceutical Science, University of Bologna, via Belmeloro 6, I-40126 Bologna, Italy. lauga@alma.unibo.it
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pubmed:publicationType |
Journal Article
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