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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-9-9
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pubmed:abstractText |
Neural crest cells migrate segmentally through the rostral half of each trunk somite due to inhibitory influences of ephrins and other molecules present in the caudal-half of somites. To examine the potential role of Notch/Delta signaling in establishing the segmental distribution of ephrins, we examined neural crest migration and ephrin expression in Delta-1 mutant mice. Using Sox-10 as a marker, we noted that neural crest cells moved through both rostral and caudal halves of the somites in mutants, consistent with the finding that ephrinB2 levels are significantly reduced in the caudal-half somites. Later, mutant embryos had aberrantly fused and/or reduced dorsal root and sympathetic ganglia, with a marked diminution in peripheral glia. These results show that Delta-1 is essential for proper migration and differentiation of neural crest cells. Interestingly, absence of Delta-1 leads to diminution of both neurons and glia in peripheral ganglia, suggesting a general depletion of the ganglion precursor pool in mutant mice.
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pubmed:grant |
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ephrin-B2,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, EphB2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/SOXE Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Sox10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/delta protein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
249
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-30
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12217323-Animals,
pubmed-meshheading:12217323-Cell Movement,
pubmed-meshheading:12217323-DNA-Binding Proteins,
pubmed-meshheading:12217323-Ephrin-B2,
pubmed-meshheading:12217323-Ganglia, Spinal,
pubmed-meshheading:12217323-Gene Expression Regulation, Developmental,
pubmed-meshheading:12217323-High Mobility Group Proteins,
pubmed-meshheading:12217323-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12217323-Membrane Proteins,
pubmed-meshheading:12217323-Mice,
pubmed-meshheading:12217323-Mice, Mutant Strains,
pubmed-meshheading:12217323-Neural Crest,
pubmed-meshheading:12217323-Neuroglia,
pubmed-meshheading:12217323-Receptor, EphB2,
pubmed-meshheading:12217323-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:12217323-Receptors, Notch,
pubmed-meshheading:12217323-SOXE Transcription Factors,
pubmed-meshheading:12217323-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.
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pubmed:affiliation |
Institut für Molekularbiologie OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, D-30625, Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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