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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-9-6
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pubmed:abstractText |
The thymidine analog (18)F-3'-deoxy-3' -fluorothymidine (FLT) is being used clinically for PET imaging of tumor proliferation. Appropriate use of this tracer requires validating the mechanisms by which it accumulates in dividing cells. We tested the accuracy with which FLT uptake predicted the activity of cytosolic thymidine kinase-1 (TK(1)), an enzyme that is upregulated before and during DNA synthesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1210-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12215561-Adenocarcinoma,
pubmed-meshheading:12215561-Cell Cycle,
pubmed-meshheading:12215561-Cell Division,
pubmed-meshheading:12215561-Culture Media,
pubmed-meshheading:12215561-Dideoxynucleosides,
pubmed-meshheading:12215561-Fluorine Radioisotopes,
pubmed-meshheading:12215561-Humans,
pubmed-meshheading:12215561-Lung Neoplasms,
pubmed-meshheading:12215561-Thymidine Kinase,
pubmed-meshheading:12215561-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.
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pubmed:affiliation |
Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington 98195, USA. rasey@u.washington.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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