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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2002-9-18
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pubmed:databankReference |
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pubmed:abstractText |
The view that parasites can develop cooperative symbiotic relationships with their hosts is both appealing and widely held; however, there is no molecular genetic evidence of such a transition. Here we demonstrate that a mutualistic bacterial endosymbiont of grain weevils maintains and expresses inv/spa genes encoding a type III secretion system homologous to that used for invasion by bacterial pathogens. Phylogenetic analyses indicate that inv/spa genes were present in presymbiotic ancestors of the weevil endosymbionts, occurring at least 50 million years ago. The function of inv/spa genes in maintaining symbiosis is demonstrated by the up-regulation of their expression under both in vivo and in vitro conditions that coincide with host cell invasion.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10028272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10097118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10334981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10359795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10508729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10535975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10742687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-10993077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-11172045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-11222580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-11390241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-11404467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-11728870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-11734881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-1729202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-3125340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-3304078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-3328816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-7466396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-8433381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-8538218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-8999810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-9089078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-9504051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-9618447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213957-9664696
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12397-402
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12213957-Adhesins, Bacterial,
pubmed-meshheading:12213957-Animals,
pubmed-meshheading:12213957-Antigens, Bacterial,
pubmed-meshheading:12213957-Base Sequence,
pubmed-meshheading:12213957-Beetles,
pubmed-meshheading:12213957-Biological Evolution,
pubmed-meshheading:12213957-Cloning, Molecular,
pubmed-meshheading:12213957-DNA, Bacterial,
pubmed-meshheading:12213957-Enterobacteriaceae,
pubmed-meshheading:12213957-Gene Expression,
pubmed-meshheading:12213957-Genes, Bacterial,
pubmed-meshheading:12213957-Molecular Sequence Data,
pubmed-meshheading:12213957-Phylogeny,
pubmed-meshheading:12213957-Symbiosis
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pubmed:year |
2002
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pubmed:articleTitle |
Type III secretion systems and the evolution of mutualistic endosymbiosis.
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pubmed:affiliation |
Department of Ecology and Evolutionary Biology, Center for Insect Science, and Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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