|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2002-9-5
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The freshwater pufferfish Tetraodon nigroviridis (TNI) has become highly attractive as a compact reference vertebrate genome for gene finding and validation. We have mapped genes, which are more or less evenly spaced on the human chromosomes 9 and X, on Tetraodon chromosomes using fluorescence in situ hybridization (FISH), to establish syntenic relationships between Tetraodon and other key vertebrate genomes. PufferFISH revealed that the human X is an orthologous mosaic of three Tetraodon chromosomes. More than 350 million years ago, an ancestral vertebrate autosome shared orthologous Xp and Xq genes with Tetraodon chromosomes 1 and 7. The shuffled order of Xp and Xq orthologs on their syntenic Tetraodon chromosomes can be explained by the prevalence of evolutionary inversions. The Tetraodon 2 orthologous genes are clustered in human Xp11 and represent a recent addition to the eutherian X sex chromosome. The human chromosome 9 and the avian Z sex chromosome show a much lower degree of synteny conservation in the pufferfish than the human X chromosome. We propose that a special selection process during vertebrate evolution has shaped a highly conserved array(s) of X-linked genes long before the X was used as a mammalian sex chromosome and many X chromosomal genes were recruited for reproduction and/or the development of cognitive abilities. [Sequence data reported in this paper have been deposited in GenBank and assigned the following accession no: AJ308098.]
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10080173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10330123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10461874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10542153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10586880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10592178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10628667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10835645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10878239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10894941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10899143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10965117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-10984453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11116085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11116086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11124517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11125045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11250153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11272793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11592480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11718922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11746227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-11752242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-1769650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-2402495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-2630186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-4554151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-7265238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-7635302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-7670496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-7741724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-8307573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-8563745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-8661105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-8854859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-9582070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-9647633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12213768-9789042
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1088-9051
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1316-22
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12213768-Animals,
pubmed-meshheading:12213768-Chickens,
pubmed-meshheading:12213768-Chromosomes, Human, Pair 9,
pubmed-meshheading:12213768-Conserved Sequence,
pubmed-meshheading:12213768-DNA,
pubmed-meshheading:12213768-Evolution, Molecular,
pubmed-meshheading:12213768-Genes,
pubmed-meshheading:12213768-Genetic Markers,
pubmed-meshheading:12213768-Humans,
pubmed-meshheading:12213768-Molecular Sequence Data,
pubmed-meshheading:12213768-Synteny,
pubmed-meshheading:12213768-Tetraodontiformes,
pubmed-meshheading:12213768-X Chromosome
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Four-hundred million years of conserved synteny of human Xp and Xq genes on three Tetraodon chromosomes.
|
|
pubmed:affiliation |
Comparative Genomics Group, Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
