Linked Life Data

12213474

Source:http://linkedlifedata.com/resource/pubmed/id/12213474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2002-9-5
pubmed:abstractText
The main objective of this investigation was to identify the reactive pharmacophore in penclomedine (PEN, 3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl) pyridine) for in vivo antitumor activity and also to discover related ring structures and sulfur analogues that might exhibit superior antitumor activity in vivo. Several new analogues of PEN and related structural variants have been synthesized and evaluated in vivo against MX-1 human breast tumor xenograft implanted subcutaneously (sc), although none of them demonstrated significant activity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0968-0896
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3593-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Determination of the phamacophore of penclomedine, a clinically-evaluated antitumor pyridine derivative.
pubmed:affiliation
Drug Discovery and Drug Development Divisions, Southern Research Institute, 2000Ninth Avenue South, Birmingham, AL 35255-5305, USA. a.tiwari@sri.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.