Linked Life Data

12210557

Source:http://linkedlifedata.com/resource/pubmed/id/12210557

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-9-4
pubmed:abstractText
P-glycoprotein (P-gp) is a plasma membrane glycoprotein that confers multidrug resistance on cells by virtue of its ability to exclude cytotoxic drugs in an ATP-dependent manner. The most commonly considered hypothesis is that P-gp acts as an ATP-driven drug-export pump, the mechanism of which is not understood in detail. Therefore, a tremendous effort is being made to find out modulator molecules to inhibit P-gp. We have been developing flavonoid derivatives as a new class of promising modulators using a new in vitro rational-screening assay based on measurements of the binding-affinity toward the C-terminal nucleotide-binding domain (NBD2) of P-gp. This review is focused on our results obtained with a variety of flavonoids. Structure-activity relationships of flavonoids as potential MDR modulators are reported.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0198-6325
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Wiley Periodicals, Inc. Med Res Rev, 22, No. 5, 512-529, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/med.10015
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
512-29
pubmed:dateRevised
2007-3-22
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.
pubmed:affiliation
Département de Pharmacochimie Moléculaire, UMR-CNRS 5063, UFR de Pharmacie de Grenoble, 38706 La Tronche, France. ahcene.boumendjel@ujf-grenoble.fr
pubmed:publicationType
Journal Article, Review