| pubmed-article:12210065 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C0042172 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C0032580 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C0555952 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C1564904 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12210065 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12210065 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12210065 | pubmed:dateCreated | 2002-9-4 | lld:pubmed |
| pubmed-article:12210065 | pubmed:abstractText | Familial adenomatous polyposis patients (FAP) harbour a germline mutation of the adenomatous polyposis coli gene (APC), and APC mutations are early events in the development of sporadic colorectal neoplasms. The APC protein interacts with beta-catenin and gamma-catenin and APC mutations are believed to play a role in the altered levels of beta-catenin in colorectal tumours. Immunohistochemical studies have shown changes in the expression and distribution of E-cadherin and catenins in sporadic colorectal neoplasms. This study assessed the expression and distribution of E-cadherin and catenins in colorectal neoplasms and non-neoplastic mucosa from FAP patients. The expression and cellular distribution of E-cadherin and catenins were studied by immunohistochemistry in 61 adenomas, five carcinomas, and non-neoplastic mucosa from 18 FAP patients. mRNA levels in the carcinomas were studied by in situ hybridization. The expression of E-cadherin and catenins was increased in over 80% of the adenomas, with evident cytoplasmic immunoreactivity. There was increased expression of E-cadherin and catenin in the carcinomas, with a notable increase in the levels of mRNA, in comparison with the non-neoplastic mucosa. | lld:pubmed |
| pubmed-article:12210065 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12210065 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210065 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12210065 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12210065 | pubmed:issn | 0022-3417 | lld:pubmed |
| pubmed-article:12210065 | pubmed:author | pubmed-author:PoulsomRichar... | lld:pubmed |
| pubmed-article:12210065 | pubmed:author | pubmed-author:JefferyRosema... | lld:pubmed |
| pubmed-article:12210065 | pubmed:author | pubmed-author:TalbotIan CIC | lld:pubmed |
| pubmed-article:12210065 | pubmed:author | pubmed-author:AlisonMalcolm... | lld:pubmed |
| pubmed-article:12210065 | pubmed:author | pubmed-author:El-BahrawyMon... | lld:pubmed |
| pubmed-article:12210065 | pubmed:copyrightInfo | Copyright 2002 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:12210065 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12210065 | pubmed:volume | 198 | lld:pubmed |
| pubmed-article:12210065 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12210065 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12210065 | pubmed:pagination | 69-76 | lld:pubmed |
| pubmed-article:12210065 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12210065 | pubmed:meshHeading | pubmed-meshheading:12210065... | lld:pubmed |
| pubmed-article:12210065 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12210065 | pubmed:articleTitle | The expression of E-cadherin and catenins in colorectal tumours from familial adenomatous polyposis patients. | lld:pubmed |
| pubmed-article:12210065 | pubmed:affiliation | Histopathology Department, Hammersmith Hospital, London, UK. | lld:pubmed |
| pubmed-article:12210065 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12210065 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12210065 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12210065 | lld:pubmed |
