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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-9-4
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pubmed:abstractText |
Familial adenomatous polyposis patients (FAP) harbour a germline mutation of the adenomatous polyposis coli gene (APC), and APC mutations are early events in the development of sporadic colorectal neoplasms. The APC protein interacts with beta-catenin and gamma-catenin and APC mutations are believed to play a role in the altered levels of beta-catenin in colorectal tumours. Immunohistochemical studies have shown changes in the expression and distribution of E-cadherin and catenins in sporadic colorectal neoplasms. This study assessed the expression and distribution of E-cadherin and catenins in colorectal neoplasms and non-neoplastic mucosa from FAP patients. The expression and cellular distribution of E-cadherin and catenins were studied by immunohistochemistry in 61 adenomas, five carcinomas, and non-neoplastic mucosa from 18 FAP patients. mRNA levels in the carcinomas were studied by in situ hybridization. The expression of E-cadherin and catenins was increased in over 80% of the adenomas, with evident cytoplasmic immunoreactivity. There was increased expression of E-cadherin and catenin in the carcinomas, with a notable increase in the levels of mRNA, in comparison with the non-neoplastic mucosa.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Desmoplakins,
http://linkedlifedata.com/resource/pubmed/chemical/JUP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/alpha Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3417
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
198
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12210065-Adenomatous Polyposis Coli,
pubmed-meshheading:12210065-Adolescent,
pubmed-meshheading:12210065-Adult,
pubmed-meshheading:12210065-Cadherins,
pubmed-meshheading:12210065-Colorectal Neoplasms,
pubmed-meshheading:12210065-Cytoplasm,
pubmed-meshheading:12210065-Cytoskeletal Proteins,
pubmed-meshheading:12210065-Desmoplakins,
pubmed-meshheading:12210065-Epithelium,
pubmed-meshheading:12210065-Female,
pubmed-meshheading:12210065-Humans,
pubmed-meshheading:12210065-Immunoenzyme Techniques,
pubmed-meshheading:12210065-In Situ Hybridization,
pubmed-meshheading:12210065-Intestinal Mucosa,
pubmed-meshheading:12210065-Male,
pubmed-meshheading:12210065-Middle Aged,
pubmed-meshheading:12210065-Neoplasm Proteins,
pubmed-meshheading:12210065-RNA, Messenger,
pubmed-meshheading:12210065-RNA, Neoplasm,
pubmed-meshheading:12210065-Trans-Activators,
pubmed-meshheading:12210065-Up-Regulation,
pubmed-meshheading:12210065-alpha Catenin,
pubmed-meshheading:12210065-beta Catenin,
pubmed-meshheading:12210065-gamma Catenin
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pubmed:year |
2002
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pubmed:articleTitle |
The expression of E-cadherin and catenins in colorectal tumours from familial adenomatous polyposis patients.
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pubmed:affiliation |
Histopathology Department, Hammersmith Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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