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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033262,
umls-concept:C0070319,
umls-concept:C0205219,
umls-concept:C0206679,
umls-concept:C0282641,
umls-concept:C0333516,
umls-concept:C0494165,
umls-concept:C0596988,
umls-concept:C1171362,
umls-concept:C1515670
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pubmed:issue |
5
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|
pubmed:dateCreated |
2002-9-4
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pubmed:abstractText |
Herpes simplex virus 1 (HSV-1) infection of cancer cells results in viral replication with cell destruction and liberation of progeny virion that infect adjacent tumor cells. rRp450 is a novel replication-conditional HSV-1 mutant that expresses both the endogenous herpes viral thymidine kinase gene and the rat p450 CYP2B1 transgene; p450 bioactivates such cancer prodrugs as cyclophosphamide.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1171-81
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12209705-Antineoplastic Agents, Alkylating,
pubmed-meshheading:12209705-Carcinoma,
pubmed-meshheading:12209705-Cell Death,
pubmed-meshheading:12209705-Colonic Neoplasms,
pubmed-meshheading:12209705-Cyclophosphamide,
pubmed-meshheading:12209705-Cytochrome P-450 CYP2B1,
pubmed-meshheading:12209705-Gene Therapy,
pubmed-meshheading:12209705-Herpesvirus 1, Human,
pubmed-meshheading:12209705-Humans,
pubmed-meshheading:12209705-Liver Neoplasms,
pubmed-meshheading:12209705-Prodrugs,
pubmed-meshheading:12209705-Transgenes,
pubmed-meshheading:12209705-Tumor Cells, Cultured,
pubmed-meshheading:12209705-Virus Replication
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pubmed:year |
2002
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pubmed:articleTitle |
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
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pubmed:affiliation |
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114-2696, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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