Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-9-4
pubmed:abstractText
The use of mycophenolate mofetil (MMF) for prophylaxis of aGVHD and/or for treatment of acute or chronic GVHD is increasing. However, the benefit of MMF as an alternative to commonly used immunosuppressive agents still needs to be assessed. We ran a retrospective study on 21 consecutive patients (median age, 36 years; range, 20-63) with aGVHD or extensive cGVHD following related (17) or unrelated (4) matched donor SCT (BM, 16; PBSC, 5) who received MMF (2 g/day) because of intolerance to or failure of CsA-containing combinations. Four of the six patients with aGVHD responded, and the response rate was 69% in cGVHD patients. We observed neither significant differences in terms of response rate for skin, liver and bowel nor dissociated response in cases of multiple organ involvement (67% of the patients). Response was the same for lichenoid and sclerodermatous skin cGVHD subtypes. No adverse effects, except diarrhea (three patients), were observed. However, 22 opportunistic or serious viral or bacterial infections occurred in 10 patients. Analysis of trough plasma levels showed a trend for a higher mean MPA concentration in patients responding to MMF. Our study highlights the high risk of infectious complications induced by the administration of MMF, an otherwise efficient and well-tolerated treatment for GVHD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0268-3369
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-95
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:12209350-Acute Disease, pubmed-meshheading:12209350-Adult, pubmed-meshheading:12209350-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:12209350-Biotransformation, pubmed-meshheading:12209350-Bone Marrow Transplantation, pubmed-meshheading:12209350-Chronic Disease, pubmed-meshheading:12209350-Drug Evaluation, pubmed-meshheading:12209350-Female, pubmed-meshheading:12209350-Graft vs Host Disease, pubmed-meshheading:12209350-Humans, pubmed-meshheading:12209350-Immunosuppressive Agents, pubmed-meshheading:12209350-Male, pubmed-meshheading:12209350-Middle Aged, pubmed-meshheading:12209350-Mycophenolic Acid, pubmed-meshheading:12209350-Opportunistic Infections, pubmed-meshheading:12209350-Peripheral Blood Stem Cell Transplantation, pubmed-meshheading:12209350-Retrospective Studies, pubmed-meshheading:12209350-Risk, pubmed-meshheading:12209350-Treatment Outcome
pubmed:year
2002
pubmed:articleTitle
Mycophenolate mofetil for the treatment of acute and chronic GVHD is effective and well tolerated but induces a high risk of infectious complications: a series of 21 BM or PBSC transplant patients.
pubmed:affiliation
Service d'Hématologie, Centre Hospito-Universitaire Hôtel-Dieu, Nantes, France.
pubmed:publicationType
Journal Article