|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
19
|
|
pubmed:dateCreated |
2002-9-18
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Loss of heterozygosity on chromosome 22q has been detected in approximately 60% of advanced nonsmall cell lung carcinoma (NSCLC) as well as small cell lung carcinoma (SCLC), suggesting the presence of a tumor suppressor gene on 22q that is involved in lung cancer progression. Here, we isolated a myosin family gene, MYO18B, located at chromosome 22q12.1 and found that it is frequently deleted, mutated, and hypermethylated in lung cancers. Somatic MYO18B mutations were detected in 19% (14/75) of lung cancer cell lines and 13% (6/46) of primary lung cancers of both SCLC and NSCLC types. MYO18B expression was reduced in 88% (30/34) of NSCLC and 47% (8/17) of SCLC cell lines. Its expression was restored by treatment with 5-aza-2'-deoxycytidine in 11 of 14 cell lines with reduced MYO18B expression, and the promoter CpG island of the MYO18B gene was methylated in 17% (8/47) of lung cancer cell lines and 35% (14/40) of primary lung cancers. Furthermore, restoration of MYO18B expression in lung carcinoma cells suppressed anchorage-independent growth. These results indicate that the MYO18B gene is a strong candidate for a novel tumor suppressor gene whose inactivation is involved in lung cancer progression.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-10591208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-10679921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-10700188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-10779630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-10837025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-11175339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-11294886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-2031185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-2231712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-3313277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-3656447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-7530487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-7882313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-7923122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-7923210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-8065911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-8504170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-8994846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-9149143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-9205089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-9338076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-9395202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-9559342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-9916919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12209013-9988266
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
pubmed-author:KobayashiKeikoK,
pubmed-author:KohnoTakashiT,
pubmed-author:MaeshimaArafumiA,
pubmed-author:MinnaJohn DJD,
pubmed-author:NikiToshiroT,
pubmed-author:NishiokaMichihoM,
pubmed-author:OtsukaAyakaA,
pubmed-author:SasakiShigeruS,
pubmed-author:SekidoYoshitakaY,
pubmed-author:SoneSaburoS,
pubmed-author:TaniMasachikaM,
pubmed-author:TomizawaYoshioY,
pubmed-author:YanaiharaNozomuN,
pubmed-author:YokotaJunJ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
99
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
12269-74
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12209013-Cell Division,
pubmed-meshheading:12209013-Chromosomes, Human, Pair 22,
pubmed-meshheading:12209013-CpG Islands,
pubmed-meshheading:12209013-DNA, Complementary,
pubmed-meshheading:12209013-DNA, Neoplasm,
pubmed-meshheading:12209013-DNA Methylation,
pubmed-meshheading:12209013-DNA Mutational Analysis,
pubmed-meshheading:12209013-Gene Deletion,
pubmed-meshheading:12209013-Gene Expression,
pubmed-meshheading:12209013-Genes, Tumor Suppressor,
pubmed-meshheading:12209013-Humans,
pubmed-meshheading:12209013-Loss of Heterozygosity,
pubmed-meshheading:12209013-Lung Neoplasms,
pubmed-meshheading:12209013-Molecular Sequence Data,
pubmed-meshheading:12209013-Mutation,
pubmed-meshheading:12209013-Myosin Heavy Chains,
pubmed-meshheading:12209013-Tumor Cells, Cultured
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
|
|
pubmed:affiliation |
National Cancer Center Research Institute, Tokyo 104-0045, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
