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pubmed:abstractText |
The herbal mixture PC-SPES, used to manage advanced prostate cancer, has proven thrombogenic and highly estrogenic in clinical trials. However, attempts to identify the active compounds in PC-SPES have yielded incongruous results. Moreover, warfarin was identified in the serum of a patient taking PC-SPES who experienced a bleeding disorder. To determine the active components in PC-SPES potentially responsible for these effects, we analyzed PC-SPES lots manufactured from l996 through mid-2001.
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pubmed:affiliation |
University of California San Diego School of Medicine, Radiology Research, and Biophysica Foundation, La Jolla, CA 92037-1023, USA. radiologyresearch@ucsd.edu
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