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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-9-4
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pubmed:abstractText |
Subclinical mutations in genes associated with the congenital long-QT syndromes (LQTS) have been suggested as a risk factor for drug-induced LQTS and accompanying life-threatening arrhythmias. Recent studies have identified genetic variants of the cardiac K+ channel genes predisposing affected individuals to acquired LQTS. We have identified a novel Na+ channel mutation in an individual who exhibited drug-induced LQTS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AiTomohikoT,
pubmed-author:HorieMinoruM,
pubmed-author:KitabatakeAkiraA,
pubmed-author:MakitaNaomasaN,
pubmed-author:NakamuraTakeshiT,
pubmed-author:OtaniHideoH,
pubmed-author:SakumaIchiroI,
pubmed-author:SakuraiMasayukiM,
pubmed-author:SasakiKojiK,
pubmed-author:SawaHirofumiH,
pubmed-author:YokoiHisatakaH
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1269-74
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:12208804-Aged,
pubmed-meshheading:12208804-Amino Acid Sequence,
pubmed-meshheading:12208804-Base Sequence,
pubmed-meshheading:12208804-Cell Line,
pubmed-meshheading:12208804-Cisapride,
pubmed-meshheading:12208804-Electric Conductivity,
pubmed-meshheading:12208804-Electrocardiography,
pubmed-meshheading:12208804-Female,
pubmed-meshheading:12208804-Genetic Predisposition to Disease,
pubmed-meshheading:12208804-Humans,
pubmed-meshheading:12208804-Ion Channel Gating,
pubmed-meshheading:12208804-Long QT Syndrome,
pubmed-meshheading:12208804-Mutation, Missense,
pubmed-meshheading:12208804-Pedigree,
pubmed-meshheading:12208804-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:12208804-Potassium Channels,
pubmed-meshheading:12208804-Sodium Channels
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pubmed:year |
2002
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pubmed:articleTitle |
Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. makitan@med.hokudai.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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