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rdf:type |
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lifeskim:mentions |
umls-concept:C0002771,
umls-concept:C0005971,
umls-concept:C0016566,
umls-concept:C0022885,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0039593,
umls-concept:C0444519,
umls-concept:C0671870,
umls-concept:C1280500,
umls-concept:C1521801,
umls-concept:C2350229
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pubmed:issue |
2
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pubmed:dateCreated |
2002-9-4
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pubmed:abstractText |
1. Orexin-A and orexin-B (also known as hypocretin-1 and hypocretin-2) are hypothalamic peptides and regulate feeding behaviour, energy metabolism and the sleep-wake cycle. Orexin-A binds equally to both orexin-1 and orexin-2 receptors, while orexin-B has a preferential affinity for orexin-2 receptors. 2. Orexins are also known to be concentrated in superficial laminae of the spinal dorsal horn, and orexin-A and orexin-1 receptors are found in the dorsal root ganglion cells. 3. In the present study, the authors examined the effect of intrathecal injection of either orexin-A or orexin-B in the rat formalin test (a model of inflammatory pain) and in the rat hot plate test. The paw formalin injection induces biphasic flinching (phase 1: 0-6 min; phase 2: 10-60 min) of the injected paw. 4. Intrathecal injection of orexin-A, but not orexin-B, decreased the sum of flinches in phases 1 and 2 in the formalin test and increased the hot plate latency. These effects of orexin-A were completely antagonized by pre-treatment with SB-334867, a selective orexin-1 receptor antagonist. Intrathecal injection of SB-334867 alone had no effect in the formalin test or in the hot plate test. 5. Intrathecal injection of orexin-A suppressed the expression of Fos-like immunoreactivity (Fos-LI), induced by paw formalin injection, in laminae I-II of L4-5 of the spinal cord. 6. These data suggest that the spinal orexin-1 receptor is involved in the nociceptive transmission and that the activation of the spinal orexin-1 receptor produces analgesic effects in the rat formalin test and in the rat hot plate test.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-10191330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-10601667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-10612711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-10773422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-10876067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-11250867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-11274794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-11309249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-11323129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-11459658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-1416174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-14677603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-2308768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-3112583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-7739801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-8090516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-8424545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-9300417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-9435201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12208773-9491897
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(2-methylbenzoxazol-6-yl)-3-(1,5)n...,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Non-Narcotic,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Urea,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
170-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12208773-Analgesics, Non-Narcotic,
pubmed-meshheading:12208773-Animals,
pubmed-meshheading:12208773-Benzoxazoles,
pubmed-meshheading:12208773-Carrier Proteins,
pubmed-meshheading:12208773-Dose-Response Relationship, Drug,
pubmed-meshheading:12208773-Immunohistochemistry,
pubmed-meshheading:12208773-Injections, Spinal,
pubmed-meshheading:12208773-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12208773-Male,
pubmed-meshheading:12208773-Naloxone,
pubmed-meshheading:12208773-Neuropeptides,
pubmed-meshheading:12208773-Pain Measurement,
pubmed-meshheading:12208773-Rats,
pubmed-meshheading:12208773-Rats, Sprague-Dawley,
pubmed-meshheading:12208773-Urea
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pubmed:year |
2002
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pubmed:articleTitle |
Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test.
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pubmed:affiliation |
Department of Anesthesiology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8677, Japan. yamatat@med.m.chiba-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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