Linked Life Data

12208144

Source:http://linkedlifedata.com/resource/pubmed/id/12208144

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-9-4
pubmed:abstractText
Part of the design of some randomized controlled trials has included asking patients to guess whether they are taking placebo or active drug. Some authors have stated that in randomized, double-blind placebo-controlled clinical trials patients in each group should guess that they are taking placebo half the time. However, this pattern should occur only under a limited set of circumstances. This paper explores the factors that affect the guess and the role of the guess in understanding both the establishment and the maintenance of the blind. It suggests that more than half of those in the treatment group should guess they are taking active drug if treatment or side-effects are powerful. Though the randomized controlled trial has become the paradigmatic tool to assess treatment efficacy, studies are still needed to validate key assumptions make by investigators and the effect of violation of these assumptions on study outcomes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0306-9877
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
In randomized controlled trials, should subjects in both placebo and drug groups be expected to guess that they are taking drug 50% of the time?
pubmed:affiliation
Department of Medicine, University of Tennessee College of Medicine-Chattanooga Unit, Tennesse 37403, USA. desbiena@erlanger.org
pubmed:publicationType
Journal Article, Comparative Study