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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-9-4
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pubmed:abstractText |
The neurofibromatosis type 2 (NF2) gene encodes an ezrin-radixin-moesin (ERM) related protein, referred to as either merlin or schwannomin, that is known to be a tumor suppressor. NF-kappaB signaling is known to be important for controlling cellular proliferation and protecting against apoptosis. In this report, merlin was demonstrated to be effective in suppressing the NF-kappaB signaling pathway in NIH3T3 and C6 cells. In addition, merlin blocked the tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB-DNA binding mediated via the inhibition of degradation of IkappaBalpha and blocked the activation of NF-kappaB-dependent transcription. A reporter gene assay using deletion mutants of NF2 showed that the N-terminus (amino acids 1-130) of merlin may be important for its inhibition of NF-kappaB activation. These results show that merlin acts as a negative regulator of the NF-kappaB signaling pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chuk protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ikbkb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ikbke protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B kinase,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Neurofibromin 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
296
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1295-302
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:12207915-3T3 Cells,
pubmed-meshheading:12207915-Animals,
pubmed-meshheading:12207915-DNA-Binding Proteins,
pubmed-meshheading:12207915-I-kappa B Kinase,
pubmed-meshheading:12207915-I-kappa B Proteins,
pubmed-meshheading:12207915-Mice,
pubmed-meshheading:12207915-NF-kappa B,
pubmed-meshheading:12207915-Neurofibromin 2,
pubmed-meshheading:12207915-Protein Structure, Tertiary,
pubmed-meshheading:12207915-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12207915-Rats,
pubmed-meshheading:12207915-Signal Transduction,
pubmed-meshheading:12207915-Transcription Factor RelA,
pubmed-meshheading:12207915-Transcriptional Activation,
pubmed-meshheading:12207915-Tumor Cells, Cultured,
pubmed-meshheading:12207915-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Inhibition of NF-kappaB activation by merlin.
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pubmed:affiliation |
Department of Pharmacology, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, 137-701, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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