Source:http://linkedlifedata.com/resource/pubmed/id/12204792
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-9-2
|
| pubmed:abstractText |
We have previously shown that dietary copper supplementation modulates the formation of atherosclerotic lesions in the cholesterol-fed rabbit. In the present study, we have investigated the effects of copper supplementation on the cellular composition and characteristics of atherosclerotic lesions in cholesterol-fed NZW rabbits. Rabbits received a 1% cholesterol diet with or without 0.02% copper acetate (containing 12 and 0.3 mg copper per 100 g diet, respectively) for 12 weeks. The tunica intima was significantly smaller in the animals receiving copper supplements (0.016+/-0.005 vs. 0.068+/-0.019 mm(2), P<0.05) and this was accompanied by a significant increase in aortic copper content (4.0+/-0.8 vs. 1.8+/-0.2 microg/g tissue, P<0.05). The percentage area staining for smooth muscle cells (HHF-35 positive) was significantly lower in the intima of animals receiving copper supplements (7.13+/-1.02 vs. 9.72+/-0.82%, P<0.05). However, there were no significant differences in area staining for macrophages (RAM-11 positive) between groups (22.6+/-7.9 vs. 23.3+/-4.9%). There were also significantly fewer apoptotic cells (0.96+/-0.33 vs. 2.54+/-0.56%, P<0.005) in the aortic intima from animals supplemented with copper, but no difference in the number of proliferating cells. However, there was a reduction in intimal collagen staining (Sirius red positivity) in the animals receiving a copper supplement. Taken together, these data show that dietary copper can significantly affect the composition and progression of atherosclerotic lesions.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0021-9150
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
164
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
229-36
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12204792-Animals,
pubmed-meshheading:12204792-Aorta, Thoracic,
pubmed-meshheading:12204792-Apoptosis,
pubmed-meshheading:12204792-Arteriosclerosis,
pubmed-meshheading:12204792-Cholesterol, Dietary,
pubmed-meshheading:12204792-Copper,
pubmed-meshheading:12204792-Dietary Supplements,
pubmed-meshheading:12204792-Disease Models, Animal,
pubmed-meshheading:12204792-Female,
pubmed-meshheading:12204792-Immunohistochemistry,
pubmed-meshheading:12204792-Male,
pubmed-meshheading:12204792-Probability,
pubmed-meshheading:12204792-Rabbits,
pubmed-meshheading:12204792-Random Allocation,
pubmed-meshheading:12204792-Reference Values,
pubmed-meshheading:12204792-Sensitivity and Specificity,
pubmed-meshheading:12204792-Statistics, Nonparametric,
pubmed-meshheading:12204792-Tunica Intima
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Effect of dietary copper supplementation on cell composition and apoptosis in atherosclerotic lesions of cholesterol-fed rabbits.
|
| pubmed:affiliation |
Centre for Clinical Science and Measurement, School of Biomedical and Life Sciences, University of Surrey, Surrey GU27XH, Guildford, UK
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|