Linked Life Data

12203823

Source:http://linkedlifedata.com/resource/pubmed/id/12203823

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-8-30
pubmed:abstractText
Leukemia inhibitory factor (LIF) is essential for implantation of mouse embryos. The aim of this study was to assess the expression and regulation of LIF receptor (LIFR) and gp130 mRNA in mouse uterus during early pregnancy using in situ hybridization and reverse transcription-polymerase chain reaction (RT-PCR). A strong level of LIFR mRNA signal was detected in the luminal epithelium on day 5 of pregnancy. On day 6-8 of pregnancy, LIFR signal was mainly localized in the decidua. LIFR signal in the luminal epithelium of ovariectomized mouse was slightly stimulated by a combination of progesterone and estrogen. By RT-PCR, LIFR mRNA signal was detected in all of the uteri from day 1-8 of pregnancy, being at the highest level on day 5. A low level of gp130 mRNA signal was seen in the glandular epithelium on day 3 of pregnancy and reached a high level on day 4 of pregnancy. gp130 signal in the decidua appeared on day 6 of pregnancy and reached a high level on day 7 and 8 of pregnancy. After the ovariectomized mouse was treated with a combination of progesterone and estrogen, a strong gp130 signal was observed in the glandular epithelium, while no signal was detected after progesterone or estrogen treatment alone. By RT-PCR analysis, gp130 mRNA was detected in all of the uteri from day 1-8 of pregnancy, being at the highest level on day 4 of pregnancy. Additionally, a high level of LIFR and gp130 mRNA signal was detected in the decidua under artificial decidualization compared to the control uninjected horn. The co-expression of a high level of LIFR and gp130 mRNA in the decidua may play a key role during the decidualization and placentation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1040-452X
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12203823-Animals, pubmed-meshheading:12203823-Antigens, CD, pubmed-meshheading:12203823-Cytokine Receptor gp130, pubmed-meshheading:12203823-Decidua, pubmed-meshheading:12203823-Embryo Implantation, pubmed-meshheading:12203823-Female, pubmed-meshheading:12203823-Gene Expression Regulation, Developmental, pubmed-meshheading:12203823-In Situ Hybridization, pubmed-meshheading:12203823-Leukemia Inhibitory Factor Receptor alpha Subunit, pubmed-meshheading:12203823-Male, pubmed-meshheading:12203823-Membrane Glycoproteins, pubmed-meshheading:12203823-Mice, pubmed-meshheading:12203823-Pregnancy, pubmed-meshheading:12203823-Pregnancy, Animal, pubmed-meshheading:12203823-Pseudopregnancy, pubmed-meshheading:12203823-RNA, Messenger, pubmed-meshheading:12203823-Receptors, Cytokine, pubmed-meshheading:12203823-Receptors, OSM-LIF, pubmed-meshheading:12203823-Uterus
pubmed:year
2002
pubmed:articleTitle
Expression of leukemia inhibitory factor receptor and gp130 in mouse uterus during early pregnancy.
pubmed:affiliation
College of Life Sciences, Northeast Agricultural University, Harbin, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't