Linked Life Data

12202931

Source:http://linkedlifedata.com/resource/pubmed/id/12202931

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-8-30
pubmed:abstractText
Exposure to environmental contaminants can induce physiological changes in animals through various mechanisms. One manifestation of subclinical toxicity from polychlorinated biphenyl (PCB) exposure is the disruption of normal immune function described in numerous species, including American kestrels (Falco sparverius). In 1998, 152 mature male and female kestrels were fed either a mixture of Aroclor 1248:1254:1260 (approximately 7 mg/kg kestrel/day) through their food items, or control diets. Offspring produced by 50 breeding pairs (thus, half received in ovo PCB exposure only) were also studied. Total and differential white blood cell counts, the phytohemagglutinin (PHA) skin response, as well as thyroid hormone levels were tested in vivo in nonbreeding adults (1998 only) and nestlings (1998 and 1999). In 1999, nestlings came from three parental groups; adults exposed in 1998, birds produced by PCB-exposed parents, and unexposed birds. In 1998, directly exposed males but not females had increased total white blood cell counts driven by lymphocytosis, plus a decreased heterophil-to-lymphocyte ratio relative to controls. PCB-exposed birds had a significantly greater response to PHA than did controls, with sex as a significant factor and plasma triiodothyonine (T(3)) as a significant covariate. Levels of T(3) were significantly depressed in PCB-exposed birds of both sexes. The 1999 nestlings (F1 generation with respect to PCB exposure) did not show any effect of parental treatment group on the PHA skin response, yet T(3) remained as a significant covariate. Immunological effects are discussed in light of the antibody-mediated immunotoxicity found in the same birds and reported previously.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0090-4341
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
338-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Thyroid hormone suppression and cell-mediated immunomodulation in American kestrels (Falco sparverius) exposed to PCBs.
pubmed:affiliation
Toxicology Centre and Veterinary Pathology, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan S7N 5B3, Canada. judit.smits@usask.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't