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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-8-30
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pubmed:abstractText |
The adult brain is extremely vulnerable to various insults. The recent discovery of neural progenitors in adult mammals, however, raises the possibility of repairing damaged tissue by recruiting their latent regenerative potential. Here we show that activation of endogenous progenitors leads to massive regeneration of hippocampal pyramidal neurons after ischemic brain injury. Endogenous progenitors proliferate in response to ischemia and subsequently migrate into the hippocampus to regenerate new neurons. Intraventricular infusion of growth factors markedly augments these responses, thereby increasing the number of newborn neurons. Our studies suggest that regenerated neurons are integrated into the existing brain circuitry and contribute to ameliorating neurological deficits. These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12202033-Animals,
pubmed-meshheading:12202033-Brain Ischemia,
pubmed-meshheading:12202033-Cell Division,
pubmed-meshheading:12202033-Cell Movement,
pubmed-meshheading:12202033-Dendrites,
pubmed-meshheading:12202033-Excitatory Postsynaptic Potentials,
pubmed-meshheading:12202033-Growth Substances,
pubmed-meshheading:12202033-Hippocampus,
pubmed-meshheading:12202033-Male,
pubmed-meshheading:12202033-Microscopy, Electron,
pubmed-meshheading:12202033-Microtubule-Associated Proteins,
pubmed-meshheading:12202033-Nerve Degeneration,
pubmed-meshheading:12202033-Nerve Regeneration,
pubmed-meshheading:12202033-Neural Pathways,
pubmed-meshheading:12202033-Neuronal Plasticity,
pubmed-meshheading:12202033-Organ Culture Techniques,
pubmed-meshheading:12202033-Pyramidal Cells,
pubmed-meshheading:12202033-Rats,
pubmed-meshheading:12202033-Rats, Wistar,
pubmed-meshheading:12202033-Recovery of Function,
pubmed-meshheading:12202033-Stem Cells,
pubmed-meshheading:12202033-Synapses,
pubmed-meshheading:12202033-Transcription Factors,
pubmed-meshheading:12202033-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors.
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pubmed:affiliation |
Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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