Source:http://linkedlifedata.com/resource/pubmed/id/12201365
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2002-8-30
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| pubmed:abstractText |
Chemokines and their corresponding receptors likely play a central role in directing mononuclear cells to the graft sites during rejection. Genes for the chemokine stromal derived factor-1 (SDF1) and CC chemokine receptors CCR2 and CCR5 are characterized by polymorphisms which alter their function. We genotyped DNA of 207 liver transplant recipients by PCR or PCR-RFLP for CCR2-641, CCR5delta32, and SDF1-3'A polymorphisms, and examined their association on outcomes in liver allograft recipients. Due to the low number of patients homozygous for CCR2-641 and CCR5delta32, only the effects of their heterozygous variants were addressed in this study. None of the investigated polymorphisms showed a significant shift in gene frequency in acute rejection and rejection-free groups, or for graft survival. The gene frequency of the SDF1-3'A allele was significantly (p = 0.034) higher in patients who died (29.0%, n = 31) compared to recipients still alive (17.1%, n = 172). The mean patient survival time post transplant was 134 months in patients with SDF1 wild-type, significantly (log rank p = 0.014) longer than 98 months in patients with at least one SDF1-3'A allele. The CCR2 and CCR5 polymorphisms were not associated with significant differences in mortality rate. In conclusion, CCR2-641, CCR5delta32, and SDF1-3'A genotypes did not influence the risk for acute rejection or graft survival. However, in liver allograft recipients SDF1-3'A is significantly associated with higher mortality.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1600-6135
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
2
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
640-5
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12201365-Chemokine CXCL12,
pubmed-meshheading:12201365-Chemokines,
pubmed-meshheading:12201365-Chemokines, CXC,
pubmed-meshheading:12201365-Ethnic Groups,
pubmed-meshheading:12201365-Female,
pubmed-meshheading:12201365-Genotype,
pubmed-meshheading:12201365-Graft Rejection,
pubmed-meshheading:12201365-Graft Survival,
pubmed-meshheading:12201365-Humans,
pubmed-meshheading:12201365-Liver Transplantation,
pubmed-meshheading:12201365-Male,
pubmed-meshheading:12201365-Polymerase Chain Reaction,
pubmed-meshheading:12201365-Polymorphism, Genetic,
pubmed-meshheading:12201365-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:12201365-Receptors, CCR5,
pubmed-meshheading:12201365-Receptors, Chemokine,
pubmed-meshheading:12201365-Retrospective Studies,
pubmed-meshheading:12201365-Survival Rate,
pubmed-meshheading:12201365-Time Factors,
pubmed-meshheading:12201365-Treatment Outcome
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| pubmed:year |
2002
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| pubmed:articleTitle |
The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation.
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| pubmed:affiliation |
Division of Nephrology Mount Sinai School of Medicine, New York, NY, USA. bernd.schroppel@mssm.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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