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pubmed-article:12201246pubmed:abstractTextOsteonectin/secreted protein, acidic and rich in cysteine (SPARC) is expressed in periodontal ligaments. Therefore, a better understanding of the action of SPARC on periodontal ligament cells could help to elucidate remodelling and repair mechanisms in periodontal tissue. In the present study, we examined the effects of human platelet-derived SPARC (hp-SPARC) on the expressions of SPARC and osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF), alkaline phosphatase (ALPase) activity, matrix metalloproteinase-2 (MMP-2) production and DNA synthesis in cultures of human periodontal ligament (HPL) cells.lld:pubmed
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pubmed-article:12201246pubmed:pagination345-52lld:pubmed
pubmed-article:12201246pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12201246pubmed:articleTitleSPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells.lld:pubmed
pubmed-article:12201246pubmed:affiliationDepartment of Periodontal Medicine, Division of Frontier Medical Science, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.lld:pubmed
pubmed-article:12201246pubmed:publicationTypeJournal Articlelld:pubmed
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