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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-8-29
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pubmed:abstractText |
Osteonectin/secreted protein, acidic and rich in cysteine (SPARC) is expressed in periodontal ligaments. Therefore, a better understanding of the action of SPARC on periodontal ligament cells could help to elucidate remodelling and repair mechanisms in periodontal tissue. In the present study, we examined the effects of human platelet-derived SPARC (hp-SPARC) on the expressions of SPARC and osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF), alkaline phosphatase (ALPase) activity, matrix metalloproteinase-2 (MMP-2) production and DNA synthesis in cultures of human periodontal ligament (HPL) cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Osteonectin,
http://linkedlifedata.com/resource/pubmed/chemical/Osteoprotegerin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11B protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0904-2512
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
345-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12201246-Alkaline Phosphatase,
pubmed-meshheading:12201246-Analysis of Variance,
pubmed-meshheading:12201246-Blotting, Northern,
pubmed-meshheading:12201246-Blotting, Western,
pubmed-meshheading:12201246-Bone Remodeling,
pubmed-meshheading:12201246-Cell Count,
pubmed-meshheading:12201246-Cells, Cultured,
pubmed-meshheading:12201246-DNA,
pubmed-meshheading:12201246-Glycoproteins,
pubmed-meshheading:12201246-Humans,
pubmed-meshheading:12201246-Matrix Metalloproteinase 2,
pubmed-meshheading:12201246-Osteonectin,
pubmed-meshheading:12201246-Osteoprotegerin,
pubmed-meshheading:12201246-Periodontal Ligament,
pubmed-meshheading:12201246-RNA, Messenger,
pubmed-meshheading:12201246-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:12201246-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:12201246-Regeneration
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pubmed:year |
2002
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pubmed:articleTitle |
SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells.
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pubmed:affiliation |
Department of Periodontal Medicine, Division of Frontier Medical Science, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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