Source:http://linkedlifedata.com/resource/pubmed/id/12200783
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2002-8-29
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| pubmed:abstractText |
We evaluated the influence of portal and hepatic venous hemodynamics on the immediate and 3-month postoperative function of living donor right lobe grafts. Portal velocity was measured prospectively by ultrasound in 14 consecutive donor/recipient pairs. Velocity was converted to flow with the Moriyasu formula. Measurements were taken in donors in the operating room and in recipients at 1 hour after reperfusion and 3 months after transplant. Recipient liver function tests were measured postoperatively. Prereperfusion and postreperfusion liver biopsies were evaluated and correlated with the hemodynamic and biochemical results. There were 11 male (78.6%) and 3 female donors (mean age, 38.9 +/- 9.8 years) for 10 male (71.4%) and 4 female recipients (mean age, 49.3 +/- 14 years). The mean graft/recipient weight ratio was 1.22 +/- 0.3. The mean right portal vein pressure was 8 +/- 1.8 mm Hg in donors versus 13 +/- 4.7 mm Hg in recipients (P < .05). The mean peak flow velocity (Vmax) in the portal vein in donors was 47.6 +/- 12.8 cm/sec (normal, 44 cm/sec). One hour after graft reperfusion in the recipient, the mean portal Vmax was significantly higher at 94.7 +/- 28.4 cm/sec (P = .004), but by 3 months follow-up, mean portal Vmax had fallen to 58.8 +/- 37.8 (P = .01). Recipient portal vein Vmax highly correlated with portal flow (r = 0.7, P = .01). Increased recipient total bilirubin on postoperative day 2 correlated highly with higher recipient portal flow one hour after transplant (r = 0.6; P =.03). Portal vein velocity/flow dramatically increases after reperfusion, returning to baseline about 3 months after transplant. Evaluation of hepatic and portal venous flow is a relatively easy skill to acquire. Intraoperative ultrasound may enable the surgeon to predict graft dysfunction and possibly, may be used to implement pre-emptive therapies.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1527-6465
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| pubmed:author |
pubmed-author:EmreSukruS,
pubmed-author:FishbeinThomas MTM,
pubmed-author:FlormanSanderS,
pubmed-author:GondolesiGabriel EGE,
pubmed-author:HuangRuoqingR,
pubmed-author:MatsumotoCalC,
pubmed-author:MillerCharles MCM,
pubmed-author:SchwartzMyron EME,
pubmed-author:ShapiroRobertR,
pubmed-author:SheinerPatricia APA,
pubmed-author:ThungSwanS
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| pubmed:issnType |
Print
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| pubmed:volume |
8
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
809-13
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12200783-Adult,
pubmed-meshheading:12200783-Bilirubin,
pubmed-meshheading:12200783-Blood Flow Velocity,
pubmed-meshheading:12200783-Female,
pubmed-meshheading:12200783-Hemodynamics,
pubmed-meshheading:12200783-Hepatic Veins,
pubmed-meshheading:12200783-Humans,
pubmed-meshheading:12200783-Liver Transplantation,
pubmed-meshheading:12200783-Living Donors,
pubmed-meshheading:12200783-Male,
pubmed-meshheading:12200783-Middle Aged,
pubmed-meshheading:12200783-Portal Vein,
pubmed-meshheading:12200783-Prospective Studies,
pubmed-meshheading:12200783-Ultrasonography, Doppler
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| pubmed:year |
2002
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| pubmed:articleTitle |
Venous hemodynamics in living donor right lobe liver transplantation.
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| pubmed:affiliation |
The Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. gabriel.gondolesi@mountsinai.org
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| pubmed:publicationType |
Journal Article
|