Linked Life Data

12200680

Source:http://linkedlifedata.com/resource/pubmed/id/12200680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2002-8-29
pubmed:abstractText
Therapy-related myelodysplastic syndrome and acute myelogenous leukemia (t-MDS/AML) are serious complications of chemotherapy and radiotherapy for cancer. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may be associated with an increased incidence of these complications. The frequency of t-MDS/AML after ASCT for breast cancer is uncertain. We reviewed our database of 379 consecutive breast cancer ASCT patients treated with alkylator-based chemotherapy, followed for a median of 1.52 years (range 0-8.97), with a median survival of 6.16 years. Three patients have developed tMDS/AML. The probability of developing this complication at 5 years is 0.032 in our series. We have used pathologic, cytogenetic and molecular methods to evaluate which portions of therapy may have predisposed to the development of this complication. Cytogenetic abnormalities were not found in the stem cell harvests of these patients by metaphase analysis or by fluorescence in situ hybridization (FISH). One patient demonstrated a clonal X chromosome inactivation pattern in her stem cell harvest, indicating pre-transplant chemotherapy may have been responsible for the development of her leukemia. As two of our patients developed this complication at greater than 4 years post-transplant, the number of cases may increase with longer follow-up. While the incidence appears to be low, further prospective and retrospective analysis will be necessary to determine which portions of therapy predispose to the development of t-MDS/AML in patients undergoing ASCT for treatment of breast cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1673-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12200680-Acute Disease, pubmed-meshheading:12200680-Adult, pubmed-meshheading:12200680-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:12200680-Breast Neoplasms, pubmed-meshheading:12200680-Carcinoma, Ductal, Breast, pubmed-meshheading:12200680-Chromosome Aberrations, pubmed-meshheading:12200680-Cyclophosphamide, pubmed-meshheading:12200680-DNA, Neoplasm, pubmed-meshheading:12200680-Doxorubicin, pubmed-meshheading:12200680-Female, pubmed-meshheading:12200680-Fluorouracil, pubmed-meshheading:12200680-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:12200680-Humans, pubmed-meshheading:12200680-In Situ Hybridization, Fluorescence, pubmed-meshheading:12200680-Karyotyping, pubmed-meshheading:12200680-Leukemia, Myeloid, pubmed-meshheading:12200680-Middle Aged, pubmed-meshheading:12200680-Myelodysplastic Syndromes, pubmed-meshheading:12200680-Neoplasms, Second Primary, pubmed-meshheading:12200680-Predictive Value of Tests, pubmed-meshheading:12200680-Receptors, Androgen, pubmed-meshheading:12200680-Retrospective Studies, pubmed-meshheading:12200680-Survival Rate, pubmed-meshheading:12200680-Time Factors, pubmed-meshheading:12200680-Transplantation, Autologous, pubmed-meshheading:12200680-Transplantation Conditioning
pubmed:year
2002
pubmed:articleTitle
Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for breast cancer.
pubmed:affiliation
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't