Linked Life Data

12200114

Source:http://linkedlifedata.com/resource/pubmed/id/12200114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-8-29
pubmed:abstractText
The proinflammatory cytokine, interleukin-6 (IL-6), seems to be involved in the pathogenesis and progression of IgA nephropathy. Moreover, the transcriptional activity of the IL-6 gene and the plasma levels of IL-6 protein are associated with a single G/C base exchange polymorphism at position -174 of the IL-6 gene promoter. Using PCR-RFLP and PCR product sequencing, we examined the -174 polymorphism in 104 IgA nephropathy patients and in 53 of the normal Korean population. Only 2 GC heterozygous variants and no CC homozygous variants were found (C allele frequency=0.006). These results suggest that the frequency of the C allele in the Korean population is considerably lower than in the Caucasian population, and it appears that the -174 G to C polymorphism of IL-6 is very rare in Eastern Asians. And, the IL-6 polymorphism at -174 is unlikely to contribute significantly to susceptibility to or the progression of IgA nephropathy in Koreans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1043-4666
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The --174 G to C polymorphism of interleukin-6 gene is very rare in koreans.
pubmed:affiliation
Department of Internal Medicine, Seoul Municipal Boramae Hospital, Seoul, Korea. cslimjy@snu.ac.kr
pubmed:publicationType
Journal Article