Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-8-28
pubmed:abstractText
Denatured syngeneic liver tissue prepared by mechanical procedures was intraperitoneally injected into adult C57BL/6 mice. In parallel with a decrease in the total number of lymphocytes in the liver, spleen, and thymus from days 1-7 after the injection, the proportion of the CD4+NK1.1+CD3(int) subset of these cells (i.e. natural killer T or NKT cells) increased in the liver. Even the absolute number of these NKT cells increased in the liver on days 14 and 21. In response to the injection of denatured liver tissue, tissue damage was induced in the liver, as shown by elevated levels of serum transaminases and hepatocyte degeneration observed by electron microscopy. Sera obtained on days 7 and 14 contained autoantibodies including anti-DNA antibodies. The proportion of CD1d(high)B cells in the liver was found to decrease on days 1-7. In other words, denatured liver tissue stimulated both NKT cells and certain B cells in the liver. These results suggest that liver lymphocytes might contain not only autoreactive T cells (e.g. CD3(int) or NKT cells) but also some B cells (e.g. B-1 cells) which produce autoantibodies and that the denatured tissue had the potential to stimulate these lymphocytes and to evoke an autoimmune-like state.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10087183, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10229833, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10330271, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10352254, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10510086, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10594694, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10634613, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10733547, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-10940881, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-11015434, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-11359810, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-6607792, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7500054, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7538697, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7650483, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7673715, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7691723, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7862661, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7904900, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-7908323, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8386744, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8418197, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8515083, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8525383, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8580071, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8621946, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8760822, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8786337, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8911142, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-8943429, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9013957, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9227320, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9252138, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9374462, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9374463, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9529321, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9531266, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9636678, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9670050, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9712035, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9815260, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9826697, http://linkedlifedata.com/resource/pubmed/commentcorrection/12197879-9952024
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-404
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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