| pubmed-article:12197835 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12197835 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12197835 | lifeskim:mentions | umls-concept:C0812299 | lld:lifeskim |
| pubmed-article:12197835 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:12197835 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:12197835 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12197835 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12197835 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:12197835 | pubmed:dateCreated | 2002-11-20 | lld:pubmed |
| pubmed-article:12197835 | pubmed:abstractText | Insulin regulates the activity of the AP-1 (activator protein-1) transcriptional complex in several cell types. One component of the AP-1 complex is the transcription factor Fra-1 (fos-related antigen-1), and we have demonstrated previously that insulin stimulates the expression of Fra-1 mRNA in CHO.T cells [Griffiths, Black, Culbert, Dickens, Shaw, Gillespie and Tavaré (1998) Biochem. J. 335, 19-26]. Here we demonstrate that insulin stimulates the activity of a fra-1 promoter linked to a luciferase reporter gene, indicating that the ability of insulin to induce expression of Fra-1 mRNA is due, at least in part, to an increase in gene transcription. Furthermore, we found that insulin induces the serine phosphorylation of Fra-1 and reduces its mobility during SDS/PAGE as a result of phosphorylation. The ability of insulin to induce the accumulation of Fra-1 mRNA, stimulate the fra-1 promoter and stimulate phosphorylation of Fra-1 all require the mitogen-activated protein (MAP) kinase cascade, which leads to the activation of extracellular-signal-regulated kinase (Erk) 1/2. Consequently, our results demonstrate that the Erk cascade plays a dual role in the co-ordinated regulation of the transcription and the phosphorylation of Fra-1 by insulin. | lld:pubmed |
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| pubmed-article:12197835 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12197835 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12197835 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12197835 | pubmed:author | pubmed-author:TavaréJeremy... | lld:pubmed |
| pubmed-article:12197835 | pubmed:author | pubmed-author:CulbertAinsle... | lld:pubmed |
| pubmed-article:12197835 | pubmed:author | pubmed-author:HurdToby WTW | lld:pubmed |
| pubmed-article:12197835 | pubmed:author | pubmed-author:WebsterKennet... | lld:pubmed |
| pubmed-article:12197835 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12197835 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12197835 | pubmed:pagination | 573-80 | lld:pubmed |
| pubmed-article:12197835 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:12197835 | pubmed:articleTitle | Dual role for mitogen-activated protein kinase (Erk) in insulin-dependent regulation of Fra-1 (fos-related antigen-1) transcription and phosphorylation. | lld:pubmed |
| pubmed-article:12197835 | pubmed:affiliation | Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, U.K. | lld:pubmed |
| entrez-gene:14283 | entrezgene:pubmed | pubmed-article:12197835 | lld:entrezgene |
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