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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-8-27
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pubmed:abstractText |
Mammalian mel-18 is a member of the polycomb group, and it acts as a transcriptional repressor with DNA binding activity. Murine mel-18 negatively regulates the cell cycle through the c-myc/cdc25 cascade, and mice haploinsufficient for mel-18 develop mammary gland tumors. In addition, the human homolog of mel-18 is located at 17q, on which candidate tumor suppressor genes for breast cancer have been suggested for a long time. These observations indicate that the mel-18 gene may be a tumor suppressor gene for breast cancer. To investigate this possibility, we examined the expression of mel-18 mRNA in human breast cancer cell lines and searched for mel-18 gene mutations in sporadic and familial breast cancers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1340-6868
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12196719-Adult,
pubmed-meshheading:12196719-Aged,
pubmed-meshheading:12196719-Breast Neoplasms,
pubmed-meshheading:12196719-DNA Primers,
pubmed-meshheading:12196719-DNA-Binding Proteins,
pubmed-meshheading:12196719-Female,
pubmed-meshheading:12196719-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12196719-Genetic Predisposition to Disease,
pubmed-meshheading:12196719-Humans,
pubmed-meshheading:12196719-Loss of Heterozygosity,
pubmed-meshheading:12196719-Middle Aged,
pubmed-meshheading:12196719-Mutation,
pubmed-meshheading:12196719-Polymerase Chain Reaction,
pubmed-meshheading:12196719-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:12196719-RNA, Messenger,
pubmed-meshheading:12196719-Repressor Proteins,
pubmed-meshheading:12196719-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines.
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pubmed:affiliation |
Department of Molecular Diagnosis, Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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