Source:http://linkedlifedata.com/resource/pubmed/id/12195346
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2002-8-26
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| pubmed:abstractText |
To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n=365) or low-grade squamous epithelial lesions (LSILs; n=275) or who were cytologically normal (control subjects; n=681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1899
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| pubmed:author |
pubmed-author:BarnesWillard AWA,
pubmed-author:BrattiM ConcepcionMC,
pubmed-author:BurkRobert DRD,
pubmed-author:CarringtonMaryM,
pubmed-author:GaoXiaojiangX,
pubmed-author:GlassAndrew GAG,
pubmed-author:GreenbergMitchell DMD,
pubmed-author:HerreroRolandoR,
pubmed-author:HildesheimAllanA,
pubmed-author:KarackiPeterP,
pubmed-author:McGowanLarryL,
pubmed-author:MortelRodrigueR,
pubmed-author:SchiffmanMarkM,
pubmed-author:SchwartzPeter EPE,
pubmed-author:ShermanMark EME,
pubmed-author:WangSophia SSS,
pubmed-author:ZainoRichard JRJ
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
186
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
598-605
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| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:12195346-Alleles,
pubmed-meshheading:12195346-Carcinoma, Squamous Cell,
pubmed-meshheading:12195346-Cohort Studies,
pubmed-meshheading:12195346-Costa Rica,
pubmed-meshheading:12195346-DNA, Viral,
pubmed-meshheading:12195346-Female,
pubmed-meshheading:12195346-HLA-C Antigens,
pubmed-meshheading:12195346-Histocompatibility Antigens Class I,
pubmed-meshheading:12195346-Humans,
pubmed-meshheading:12195346-Logistic Models,
pubmed-meshheading:12195346-Oregon,
pubmed-meshheading:12195346-Papillomaviridae,
pubmed-meshheading:12195346-Papillomavirus Infections,
pubmed-meshheading:12195346-Polymerase Chain Reaction,
pubmed-meshheading:12195346-Tumor Virus Infections,
pubmed-meshheading:12195346-Uterine Cervical Neoplasms
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies.
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| pubmed:affiliation |
Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7234, USA. wangso@mail.nih.gov
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|