| pubmed-article:12194869 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12194869 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12194869 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:12194869 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:12194869 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:12194869 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:12194869 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12194869 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12194869 | pubmed:dateCreated | 2002-8-26 | lld:pubmed |
| pubmed-article:12194869 | pubmed:abstractText | Cell survival is determined by a balance among signaling cascades, including those that recruit the Akt and JNK pathways. Here we describe a novel interaction between Akt1 and JNK interacting protein 1 (JIP1), a JNK pathway scaffold. Direct association between Akt1 and JIP1 was observed in primary neurons. Neuronal exposure to an excitotoxic stimulus decreased the Akt1-JIP1 interaction and concomitantly increased association between JIP1 and JNK. Akt1 interaction with JIP1 inhibited JIP1-mediated potentiation of JNK activity by decreasing JIP1 binding to specific JNK pathway kinases. Consistent with this view, neurons from Akt1-deficient mice exhibited higher susceptibility to kainate than wild-type littermates. Overexpression of Akt1 mutants that bind JIP1 reduced excitotoxic apoptosis. These results suggest that Akt1 binding to JIP1 acts as a regulatory gate preventing JNK activation, which is released under conditions of excitotoxic injury. | lld:pubmed |
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| pubmed-article:12194869 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12194869 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12194869 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12194869 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12194869 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:ChaoMoses VMV | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:KimAlbert HAH | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:MargolisBenB | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:BirnbaumMorri... | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:YanoHirokoH | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:ChoHanH | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:MeyerDebraD | lld:pubmed |
| pubmed-article:12194869 | pubmed:author | pubmed-author:MonksBobB | lld:pubmed |
| pubmed-article:12194869 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12194869 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12194869 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:12194869 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12194869 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12194869 | pubmed:pagination | 697-709 | lld:pubmed |
| pubmed-article:12194869 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12194869 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12194869 | pubmed:articleTitle | Akt1 regulates a JNK scaffold during excitotoxic apoptosis. | lld:pubmed |
| pubmed-article:12194869 | pubmed:affiliation | Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA. | lld:pubmed |
| pubmed-article:12194869 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12194869 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12194869 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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